The aim of this investigation was to establish the criteria of service, reception and set that determine setting efficacy in world-class top-level volleyball. The study sample consisted of 4.113 gaming actions (1.371 serve actions, 1.371 reception actions, and 1.371 set actions), corresponding to the observation of four matches for each of the 12 best ranked teams in the Volleyball World Championship -a total of 23 matches. The criteria were: in-game role of the server, serve zone, type of serve, striking technique and serve direction; receiver player, reception zone, and reception efficacy; setting zone, type of set, setting technique, setting efficacy, a set's area, and set tempo. Multinomial logistic regression showed that criteria related to reception (reception efficacy) and to set (setting zone, type of set, a set's area, and set tempo) determined set efficacy. Specifically, positive and negative receptions and settings from acceptable and nonacceptable zones reduced perfect setting. In contrast, the jump set toward zones three and six and the first and second tempo increased perfect setting. Serve criteria did not determine set efficacy. This study can guide trainers and players in the training process.