“…The ecological, biological, demographical, socio-economical, and epidemiological characteristics of La Macarena municipality, facilitate arboviral transmission [ 13 , 14 ]. Factors increasing the risk of changes in arboviral transmission dynamics in the region include international tourism, the extraction of natural resources, and extending the agricultural borders to sylvatic areas, activities amplified after peace agreements [ 15 ]. This study explored a multidisciplinary approach to analyze arbovirus transmission through vectors, and identify biological and sociodemographic determinants associated with their transmission risk in urban and rural areas in a Colombian municipality.…”