Análisis de la tendencia de la mortalidad por cirrosis hepática en Chile: Años 1990 a 2007

Alonso, Faustino; Garmendia, María Luisa; Aguirre, M de; Searle, Javier

doi:10.4067/s0034-98872010001100007

Cited by 18 publications

(19 citation statements)

References 8 publications

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“…In comparison with data from the Americas, the mortality rate is similar to that reported in Chile 10 , and higher than that recently reported in Mexico 11 , the United States and Canada 1 . In comparison with European countries, the mortality ratio is similar to that reported in Western European countries and lower than in the United Kingdom (Scotland) and Eastern Europe 1,12 .…”

Section: Para Estudar a Mortalidade E Conferir A Etiologia Da Cirrosesupporting

confidence: 81%

“…In 262 cases in which the aetiology was confirmed (reviewed sample) the male-to-female ratio was significantly higher and Age adjusted and standardized mortality rates from liver cirrhosis, with or without corrections for death certificates attested as R98 and R99 (without medical care or ill-defined causes), in Espírito Santo State, Southeast Brazil. the age of death was significantly lower in patients with alcoholic cirrhosis than non-alcoholic cirrhosis (data not shown), as demonstrated in other countries 10 .…”

Section: Para Estudar a Mortalidade E Conferir A Etiologia Da Cirrosesupporting

confidence: 75%

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Mortality from liver cirrhosis in Espírito Santo State, Brazil

Gonçalves¹,

Gonçalves²,

Pereira

2014

Cad. Saúde Pública

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To study mortality from liver cirrhosis in Espírito Santo State, Brazil, we reviewed death certificates (DC) from 2000-2010 and medical records of deceased patients with investigation of alcoholism and hepatitis B or C. From a total of 218,410 DC, 3,554 deaths from liver cirrhosis were retrieved. The annual mortality rate was 19.8/100,000 for men and 4.31/100,000 for women, without significant changes after correction for ICD-R98 and R99 and without a significant increase in the annual percentage change. In 49% of death certificates, the aetiology of cirrhosis was defined: of these alcoholism in 81.5% of cases and viral hepatitis in 15.7%. Aetiology was confirmed in 262 reviewed records, including alcoholism (40.5%); hepatitis B or C (26.7%); other (3.8%); and cryptogenic (10.6%). The mean annual potential years of life lost were 5,946 years and 1,739 years for men and women respectively. The mortality rate from cirrhosis in Espírito Santo State is intermediate in relationship to worldwide data; alcoholism and hepatitis B or C were the main aetiologies; probably alcoholism is overestimated and hepatitis B and C viruses are underestimated as causes of cirrhosis registered on death certificates.

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Section: Para Estudar a Mortalidade E Conferir A Etiologia Da Cirrosesupporting

confidence: 81%

Section: Para Estudar a Mortalidade E Conferir A Etiologia Da Cirrosesupporting

confidence: 75%

Mortality from liver cirrhosis in Espírito Santo State, Brazil

Gonçalves¹,

Gonçalves²,

Pereira

2014

Cad. Saúde Pública

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“…Heavy alcohol consumption is likely to be the main cause of liver cirrhosis in most parts of Latin America [20,70–72] (Figure 2, Additional file 6: Table S6). However, large declines in cirrhosis mortality in Mexico and Chile were observed without significant changes in alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

“…The immediate and intermediate causes of death are attributed to the underlying cause. Consequently, there has been large variation in assignment of ICD codes to liver cirrhosis deaths across the published literature, and no standard definition has been consistently utilized [20–23]. Based on the GBD2010 Gastrointestinal Diseases expert group recommendations, we included in our definition the following underlying causes of death: liver cirrhosis, chronic viral hepatitis infections and hepatic decompensation events.…”

Section: Methodsmentioning

confidence: 99%

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

Mokdad

López

Shahraz

et al. 2014

BMC Med

964

731

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BackgroundLiver cirrhosis is a major yet largely preventable and underappreciated cause of global health loss. Variations in cirrhosis mortality at the country level reflect differences in prevalence of risk factors such as alcohol use and hepatitis B and C infection. We estimated annual age-specific mortality from liver cirrhosis in 187 countries between 1980 and 2010.MethodsWe systematically collected vital registration and verbal autopsy data on liver cirrhosis mortality for the period 1980 to 2010. We corrected for misclassification of deaths, which included deaths attributed to improbable or nonfatal causes. We used ensemble models to estimate liver cirrhosis mortality with uncertainty by age, sex, country and year. We used out-of-sample predictive validity to select the optimal model.ResultsGlobal liver cirrhosis deaths increased from around 676,000 (95% uncertainty interval: 452,863 to 1,004,530) in 1980 to over 1 million (1,029,042; 670,216 to 1,554,530) in 2010 (about 2% of the global total). Over the same period, the age-standardized cirrhosis mortality rate decreased by 22%. This was largely driven by decreasing cirrhosis mortality rates in China, the US and countries in Western Europe. In 2010, Egypt, followed by Moldova, had the highest age-standardized cirrhosis mortality rates, 72.7 and 71.2 deaths per 100,000, respectively, while Iceland had the lowest. In Egypt, almost one-fifth (18.1%) of all deaths in males 45- to 54-years old were due to liver cirrhosis. Liver cirrhosis mortality in Mexico is the highest in Latin America. In France and Italy, liver cirrhosis mortality fell by 50% to 60%; conversely, in the United Kingdom, mortality increased by about one-third. Mortality from liver cirrhosis was also comparatively high in Central Asia countries, particularly Mongolia, Uzbekistan and Kyrgyzstan, and in parts of sub-Saharan Africa, notably Gabon.ConclusionsLiver cirrhosis is a significant cause of global health burden, with more than one million deaths in 2010. Our study identifies areas with high and/or rapidly increasing mortality where preventive measures to control and reduce liver cirrhosis risk factors should be urgently strengthened.Please see related commentary: http://www.biomedcentral.com/1741-7015/12/159/abstract.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-014-0145-y) contains supplementary material, which is available to authorized users.

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“…La elección de contendidos de gastroenterología, como tópicos a abordar en estos cursos, se sustenta en la importancia de la patología de tubo digestivo, siendo el cáncer gástrico y de vesícula las neoplasias con mayor mortalidad en la población chilena. Por otra parte, la cirrosis hepática, con una tasa de mortalidad 16,6/100.000 habitantes, es una de las causas específicas de mortalidad más importantes en nuestro país 19 . Esto, sumado a la alta frecuencia de consulta por patología gastroenterológica en los servicios de urgencia, en donde sólo la diarrea aguda constituye entre 4 a 4,3% de las consultas en los servicios de urgencia públicos del país 20 , son razones más que suficientes para la realización de cursos sobre el manejo de este grupo de patologías de alta prevalencia en Chile e Iberoamérica.…”

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