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Dislipidemia is one of the main risk factors of cardiovascular diseases that contributed more than 25% of death in this world. Hypertension and DM are associated with comorbidity in chronic disease, include of dislipidemia. This study aimed to determine the effect of comorbid and type of therapy on clinical outcomes in the outpatient installation at Puskesmas Jetis, Yogyakarta. This research is descriptive observational analytic with a cross-sectional. Data derived from primary data and secondary data. The inclusion criteria were patients dyslipidemia, received antidyslipidemia at least 3 months before the study, completed medical record, willing to able respondents, and can communicate well. Those who were pregnant or breastfeeding were excluded from the study. Data analysis used the Wilcoxon test. Most of respondents were majority dominated by women (86,14%), hypertension is the most comorbid (42,46%), most of patients used simvastatin (76,24%), gemfibrozil (16,83%), and combination of simvastatin+gemfibrozil (6,93%). The analysis showed that there was a significant effect on patients with comorbid diabetes and used simvastatin value before and after therapy for 3 months (p<0,05). This result showed that there was an effect of diabetes comorbidities and simvastatin therapy on the total cholesterol of patients, So this study implies that in providing statin therapy need to consider comorbid because they will affect to total cholesterol which one comorbid management that good need to achieve optimal therapeutic and type of therapy must be correct to improve outcome.
Dislipidemia is one of the main risk factors of cardiovascular diseases that contributed more than 25% of death in this world. Hypertension and DM are associated with comorbidity in chronic disease, include of dislipidemia. This study aimed to determine the effect of comorbid and type of therapy on clinical outcomes in the outpatient installation at Puskesmas Jetis, Yogyakarta. This research is descriptive observational analytic with a cross-sectional. Data derived from primary data and secondary data. The inclusion criteria were patients dyslipidemia, received antidyslipidemia at least 3 months before the study, completed medical record, willing to able respondents, and can communicate well. Those who were pregnant or breastfeeding were excluded from the study. Data analysis used the Wilcoxon test. Most of respondents were majority dominated by women (86,14%), hypertension is the most comorbid (42,46%), most of patients used simvastatin (76,24%), gemfibrozil (16,83%), and combination of simvastatin+gemfibrozil (6,93%). The analysis showed that there was a significant effect on patients with comorbid diabetes and used simvastatin value before and after therapy for 3 months (p<0,05). This result showed that there was an effect of diabetes comorbidities and simvastatin therapy on the total cholesterol of patients, So this study implies that in providing statin therapy need to consider comorbid because they will affect to total cholesterol which one comorbid management that good need to achieve optimal therapeutic and type of therapy must be correct to improve outcome.
ABSTRAK Berdasarkan hasil pemeriksaan kesehatan berkala yang dilakukan perusahaan, terdapat trend masalah kesehatan dislipidemia. Dislipidemia ditandai dengan gangguan metabolisme lipid berupa peningkatan kadar kolesterol total, low density lipoprotein (LDL-C), trigliserida, dan atau penurunan high density lipoprotein (HDL-C). Dislipidemia berbahaya karena dapat meningkatkan risiko penyakit jantung koroner dan stroke. Penelitian ini bertujuan untuk mengidentifikasi faktor risiko yang berhubungan dengan dislipidemia. Desain penelitian ini adalah penelitian kuantitatif dengan metode potong lintang. Populasi berjumlah 85 orang merupakan responden sehingga tidak menggunakan teknik pengambilan sampel probabilitas. Data yang dilakukan analisis adalah data sekunder. Data usia, jenis kelamin, riwayat penyakit keluarga, gaya hidup, BMI, tekanan darah, dan LDL-C diperoleh melalui hasil pemeriksaan kesehatan pada tahun 2022. Teknik analisis data yang digunakan adalah tabulasi silang dengan menilai estimasi koefisien asosiasi Odd Ratio (OR), uji hipotesis menggunakan Kai Kuadrat dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa prevalensi kejadian dislipidemia adalah 67,1% dan 2,7 kali lebih besar dari angka prevalensi dislipidemia nasional. Tidak terdapat hubungan bermakna antara faktor risiko dengan kejadian dislipidemia sehingga usia, jenis kelamin, riwayat penyakit, gaya hidup, BMI, dan tekanan darah bukan merupakan faktor risiko kejadian dislipidemia. Promosi kesehatan perlu intensif dilakukan untuk menurunkan prevalensi kejadian dislipidemia karyawan PT.X. Kata Kunci : dislipidemia, faktor risiko, pemeriksaan kesehatan ABSTRACT Based on the results of company’s periodic health examination, there was a trend of dyslipidemia. Dyslipidemia is associated with lipid metabolism disorders of increased levels of total cholesterol, low density lipoprotein (LDL-C), triglycerides, and or decreased high density lipoprotein (HDL-C). Dyslipidemia is dangerous because can increase the risk of coronary heart disease and stroke. The objective of the study is to identify the risk factors associated with dyslipidemia. The design of research is quantitative, cross-sectional. Population of 85 people were respondents so probability sampling techniques does not applied. Data analyzed is secondary data. Age, gender, history of disease, lifestyle, BMI, blood pressure, and LDL-C were obtained by health examination result 2022. Analysis technique was cross tabulation by assessing estimated Odd Ratio association coefficient, hypothesis testing uses Chi Square, confidence level of 95%. The results showed that the prevalence of dyslipidemia was 67.1% and 2.7 times greater than the national dyslipidemia prevalence rate. There is no significant relationship between risk factors and the incidence of dyslipidemia so that age, gender, history of disease, lifestyle, BMI and blood pressure are not risk factors of dyslipidemia. Health promotion to be carried out intensively to reduce the prevalence of dyslipidemia in PT.X. Keywords: dyslipidemia, medical check-up, risk factors
Latar Belakang: Penyakit dislipidemia merupakan salah satu penyakit yang dapat berdampak buruk bagi kesehatan manusia. Pengobatan dislipidemia memiliki 3 tingkatan berdasarkan intensitasnya yaitu penyakit dengan intensitas tinggi, intensitas menengah, dan intensitas rendah. Dalam penelitian ini obat yang di gunakan adalah Pravastatin dan Rosuvastatin yang mana kedua obat ini termasuk dalam intensitas menengah. Tujuan: Mengetahui perbandingan efektivitas obat Rosuvastatin dan Pravastatin sebagai anti dislipidemia pada tikus. Metode: Metode penelitian yang digunakan pada penelitian ini adalah True Experimental. Desain penelitian yang digunakan pada penelitian ini adalah postest only control group yaitu dengan pengambilan sampel yang dilakukan sesudah diberikan obat Rosuvastatin dan Pravastatin, sehingga akan dilihat efektivitas dari pemberian perlakuan terhadap kelompok tikus yang diuji. Hasil: Rosuvastatin lebih dapat menurunkan LDL lebih baik dari pada Pravastatin karena rosuvastatin memiliki interaksi ikatan tertinggi dengan HMG-CoA reduktase, menghasilkan penghambatan sintesis kolesterol yang paling kuat dari semua golongan statin lainnya. Pravastatin memiliki kemampuan menurunkan LDL lebih rendah. Dari hasil nilai rata-rata dari kedua obat golongan statin tersebut Rosuvastatin yang memiliki nilai rata-rata yang lebih baik dibandingkan dengan Pravastatin, namun hasil statistik dapat disimpulkan bahwa tidak terjadi perbedaan yang bermakna dari kontrol Na CMC 0,5% terhadap Rosuvastatin dibandingkan dengan Pravastatin. Simpulan: Obat golongan statin Rosuvastatin memiliki efektivitas yang lebih baik dibandingkan dengan Pravastatin.
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