The classification of images from the Indonesian Sign Language System (SIBI) using VGG16, ResNet50, Inception, Xception, and MobileNetV2 Convolutional Neural Network (CNN) architectures is evaluated in this paper. With Google Colab Pro, a 224 × 224-pixel picture dataset was used for the study. A five-stage technique consisting of Dataset Collection, Dataset Preprocessing, Model Design, Model Training, and Model Testing was applied. Performance evaluation focused on accuracy, precision, recall, and F1-Score. The results identified VGG16 as the top-performing model with an accuracy of 99.60% and an equivalent F1-Score, followed closely by ResNet50 with nearly similar performance. Inception, XCeption, and MobileNetV2 demonstrated balanced performance but with lower accuracy. This study sheds light on the best CNN models to choose for SIBI image classification, and it makes recommendations for further research that include using sophisticated data augmentation methods, investigating novel CNN architectures, and putting the models to practical use.