Analog of mRNA, pUUUGUU derivative with an arylazide group at guanosine residue, crosslinks with nucleotides A1823 and A1824 of 18S rRNA in human 80S ribosomes

In this review we summarize data on the location of template on the human ribosome that we obtained from cross-linking (affinity labeling) experiments using reactive mRNA analogs. Types of mRNA analogs, model complexes of these analogs with 80S ribosomes, and methods for analysis of the ribosomal components (proteins and rRNA nucleotides) cross-linked with the mRNA analogs are reviewed. From analysis of the cross-linking data, we suggest a scheme for the arrangement of mRNA on the human ribosome and compare the organization of the mRNA binding center on human and Escherichia coli ribosomes.

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Demeshkina

Laletina

Meschaninova

et al. 2003

Molecular Biology

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Analog of mRNA, pUUUGUU derivative with an arylazide group at guanosine residue, crosslinks with nucleotides A1823 and A1824 of 18S rRNA in human 80S ribosomes

Cited by 4 publications

References 10 publications

Positioning of mRNA codons with respect to 18S rRNA at the P and E sites of human ribosome

Positioning of mRNA codons with respect to 18S rRNA at the P and E sites of human ribosome

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