Spanish colonial archaeology has undergone a fundamental shift since the Columbian Quincentenary due to the adoption of a bottom-up understanding of colonialism that emphasizes the analysis of local phenomena in a global context and the active ways in which people negotiated the processes set in motion by the conquest. This review examines five key research foci: culture change and identity, missionization, bioarchaeology, economics, and investigations of the colonial core. It ends with a consideration of ongoing challenges posed by the archaeology of colonialism, particularly the relationship of the individual to broader social processes and the emerging role of comparison.