Analyse de l’état du stress oxydatif dans le cancer du sein à l’Ouest algérien via les tests FORD et FORT et corrélation avec le grade histopronostique SBR

Tahari, Z.; Medjdoub, A.; Sahraoui, T.; Tahari, F. Z.; Soulimani, Rachid; Bousahba, A.; Kébir, F. Z. El

doi:10.1007/s12558-012-0236-7

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Scarff-Bloom-Richardson grade is a well-established prognostic factor in BC [ 26 ]. In our study we found that grade II is the most frequent with 64.3%, followed by grade III with 32.8%, and grade I with 2.9% of cases.…”

Section: Discussionmentioning

confidence: 99%

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

Yahia,

Tahari,

Medjdoub

et al. 2023

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Introduction Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease. The aim of this study was to evaluate the concentrations of these molecules and to find a possible correlation with the clinicopathological parameters of patients with BC from western Algeria. Material and methods We evaluated the serum levels of IL-6, 4-HNE, and HIF-1α by ELISA technique and compare them in different age groups and BC molecular subtypes, and then correlated them with clinicopathological parameters. Results Our study revealed a significant increase in 4-HNE (p < 0.05), and a negative correlation (p < 0.05) was found between IL-6 serum levels and lymph node count, but not (p > 0.05) between 4-HNE, HIF-1α and lymph node count. No significant correlation (p > 0.05) was found between IL-6, 4-HNE, HIF-1α , and Scarff-Bloom-Richardson grade. Furthermore, there was no significant difference ( p > 0.05) in serum levels of IL-6, 4-HNE, and HIF-1α in the different age groups and molecular subtypes of BC. Conclusions The data obtained show that the presence of lipid peroxidation (4-HNE) is a marker of oxidative stress, and that IL-6 is a good prognostic factor due to its negative effect on the number of lymph nodes. Furthermore, age and BC molecular subtypes do not influence the serum concentrations of IL-6,4-HNE, and HIF-1α.

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Section: Discussionmentioning

confidence: 99%

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

Yahia,

Tahari,

Medjdoub

et al. 2023

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“…A study conducted in western Algeria covering 62 breast cancer patients compared to 21 cancerfree controls, evaluating the levels of free oxygen radicals and antioxidants via FORD (free oxygen radicals defense) and FORT (free oxygen radicals test) tests, obtained significantly modified FORT/FORD ratio with increased FORT values and decreased FORD for the cancer patients [92]. The upregulation of oxidative stress markers and downregulation of the antioxidant defense system are considered one of the factors that correlate with the initiation and maintenance of breast cancer progression (Table 1) [92,93]. DNA in breast cancer was reported to contain high concentrations of base modifications, products of DNA oxidation such as the 8-hydroxydeoxyguanosine, which seem to be involved in breast cancer [94][95][96][97][98].…”

Section: Breast Cancermentioning

confidence: 99%

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Zahra

Lefter

Ali

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxygen-free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS), are known by their “double-sided” nature in biological systems. The beneficial effects of ROS involve physiological roles as weapons in the arsenal of the immune system (destroying bacteria within phagocytic cells) and role in programmed cell death (apoptosis). On the other hand, the redox imbalance in favor of the prooxidants results in an overproduction of the ROS/RNS leading to oxidative stress. This imbalance can, therefore, be related to oncogenic stimulation. High levels of ROS disrupt cellular processes by nonspecifically attacking proteins, lipids, and DNA. It appears that DNA damage is the key player in cancer initiation and the formation of 8-OH-G, a potential biomarker for carcinogenesis. The harmful effect of ROS is neutralized by an antioxidant protection treatment as they convert ROS into less reactive species. However, contradictory epidemiological results show that supplementation above physiological doses recommended for antioxidants and taken over a long period can lead to harmful effects and even increase the risk of cancer. Thus, we are describing here some of the latest updates on the involvement of oxidative stress in cancer pathology and a double view on the role of the antioxidants in this context and how this could be relevant in the management and pathology of cancer.

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Analyse de l’état du stress oxydatif dans le cancer du sein à l’Ouest algérien via les tests FORD et FORT et corrélation avec le grade histopronostique SBR

Cited by 2 publications

References 18 publications

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

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