2020
DOI: 10.1007/s00432-020-03288-6
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Analyses of expressions and prognostic values of Polo-like kinases in non-small cell lung cancer

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Cited by 17 publications
(23 citation statements)
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References 60 publications
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“…There was a 3.3 ± 0.3 and 3.4 ± 0.6-fold increase in PLK1 expression in A549 and NCI-H460 cell lines, respectively, compared to the lung non-tumor cell line. These results are in concordance with previous studies that reported a PLK1 overexpression in NSCLC, highlighting the relevance of PLK1 targeting [28,29].…”
Section: Plk1 Is Upregulated In Lung Cancer Cellssupporting
confidence: 93%
“…There was a 3.3 ± 0.3 and 3.4 ± 0.6-fold increase in PLK1 expression in A549 and NCI-H460 cell lines, respectively, compared to the lung non-tumor cell line. These results are in concordance with previous studies that reported a PLK1 overexpression in NSCLC, highlighting the relevance of PLK1 targeting [28,29].…”
Section: Plk1 Is Upregulated In Lung Cancer Cellssupporting
confidence: 93%
“…Pearson correlation analysis and mutual exclusivity analysis showed a remarkable positive correlation between PLK1 and PLK4. Zeng et al also found the same conclusion in human non-small cell lung cancer [ 30 ]. The cross talk of PLK1 with PLK4 needs to be further demonstrated.…”
Section: Discussionsupporting
confidence: 58%
“…CDC25C in the cytoplasm cannot activate the cyclin B1/CDK1 complex, resulting in the arrest of G2/M phase and the formation of PGCCs [8]. Phosphorylation of CDC25C at Ser198 by PLK1 and PLK3 promotes to the CDC25C nuclear translocation [13,43]. Ser216 of CDC25C can be phosphorylated by CHEK1 and CHK2 kinases, which promotes to the CDC25C nuclear output, and results in G2/M arrest of the cell cycle [8].…”
Section: Discussionmentioning
confidence: 99%