This study explores the contribution of metacognition awareness, science process skills, and Vee Diagrams in predicting the experimental design abilities. The statistical population involved students of the third semester Department of Biology Education at Kuningan University. From these, 28 students were selected as samples through purposive sampling. Based on the nature of the subject and the research question, the correlation method was considered the most suitable for this study. Vee Diagram assessment rubric, MAI questionnaire, and Science Process Skills test were used to collect data. For data analysis, Pearson correlation and multiple regression were used. The results showed that metacognition awareness, science process skills, and Vee Diagrams contributed significantly to designing experiments with an R-value of 0,998. Among the components of metacognitive awareness, science process skills and the Vee Diagram were -0.537, -0.742, and 1.948, respectively.