Analysis for commonly prescribed non-sedating antihistamines

Voltammetric Study of the Antihistamine Drug Bilastine: Anodic Characterization and Quantification Using a Reusable MWCNTs Modified Screen Printed Carbon Electrode

“…Bilastine (BIL, Figure 1), chemically known as 2‐[4‐(2‐(4‐[1‐(2‐ethoxyethyl)benzimidazole‐2‐yl]piperidin‐1‐yl) ethyl)phenyl]‐2‐methylpropanoic acid (or according to the World Health Organization, as p‐[2‐[4‐[1‐(2‐etoxyetyl)‐2‐benzimidazolyl]piperidino]etyl]‐ α ‐metyl‐hydratropic acid), is a second generation H1‐antihistamine, an important class of highly selective and reversible inhibitor of histamine‐1 receptors, with mildly sedative to nonsedative effects that do not cross the blood‐brain barrier and act mainly outside the central nervous system [1–3]. Pertaining to the H1‐antihistamine group of piperidines and classified as a potent and non‐sedating antihistamine with good‐to‐excellent safety profile [1, 4], bilastine is prescribed orally to symptomatic relief in chronic spontaneous urticaria and allergic rhino conjunctivitis –[5–3]. BIL is rapidly absorbed, does not interact with the cytochrome P450 system and does not undergo significant metabolism in humans, being mainly excreted as the parent compound [1, 9].…”

Development and Validation of High Performance LCMS Methods for Estimation of Ebastine and Carebastine in Human Plasma

“…Carebastine molecular formula is C32H37NO4 with average molecular weight 499.64 g/mol and available in white powder form. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Several methods were reported in literature for the determination of Ebastine and its metabolite and Ebastine with different drugs with varying analytical techniques for its estimation with its active metabolite Carebastine and in combination of drugs like phenylephrine hydrochloride with UV spectrophotometric assay method [3] , Ebastine and Montelukast sodium [1] , Reverse Phase high performance liquid chromatography (RP-HPLC) method [7] , and by high performance liquid chromatography (HPLC) [12,17] by spectrometric methods [10] electrochemical determination [14] and gas chromatography-mass spectrometry (GC-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS) [2] and ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). [11] The reported method of quantification in LC-MS/MS was validated over the concentration range of 0.1-10 ng/mL for Ebastine and 0.2-200 ng/ mL for Carebastine in human plasma, respectively.…”

LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma

“…H 1 -antihistamines (H 1 receptor antagonists) competitively block histamine at H 1 receptors and prevent the characteristic H 1 -type effects of histamine released after antigen-antibody interaction. Currently, H 1antihistamines represent the second most commonly used class of drugs, after antibiotics, with more than 40 varieties used in medical practice worldwide [1]. H 1 -antihistamines, desloratadine (DSL), loratadine (LOR) and cetirizine (CTZ), are members of a very frequent used class of drugs, in children and adults, for the treatment of various allergic manifestations, even without a medical prescription.…”