Analysis for Science Librarians of the 2015 Nobel Prize in Physiology or Medicine: The Life and Work of William C. Campbell, Satoshi Ōmura, and Youyou Tu

Gilman, Neyda

doi:10.1080/0194262x.2016.1154493

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…With the 2015 Nobel Prize in Physiology or Medicine being awarded to artemisinin and abamectin 6 , medicinal products from natural resources have been proposed to worldwide attention again. Among them, spider venom is considered to be an ideal source of potentially active peptides due to the tremendous biochemical diversity of spider venom peptides in diverse species.…”

Section: Introductionmentioning

confidence: 99%

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Tan¹,

Huang²,

Xu³

et al. 2017

Theranostics

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Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells. The spider venom peptide, lycosin-I, is a CPP with potent cytotoxicity to cancer cells, which might enable lycosin-I to deliver functional materials into cancer cells selectively. In this study, we demonstrated that the lycosin-I-conjugated spherical gold nanoparticles (LGNPs) not only exhibited efficient cellular internalization efficiency toward cancer cells but also displayed unprecedented selectivity over noncancerous cells. Although LGNPs were removed from the living circulatory system via reticuloendothelial system-dominant clearance modes without noticeable adverse effects to animals, they actually displayed active tumor-targeting effects and efficient accumulation in tumors in vivo. Furthermore, the potential application of this platform for cancer therapy was explored by lycosin-I-conjugated gold nanorods (LGNRs). LGNRs exhibited selective intracellular translocation towards cancer cells and efficient photothermal effect under near infrared (NIR, 808 nm) irradiation, which consequently killed cancer cells in vitro and in vivo effectively. Therefore, the established LGNPs and LGNRs possessed great potential in cancer-targeting delivery and photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Tan¹,

Huang²,

Xu³

et al. 2017

Theranostics

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show abstract

Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography–tandem mass spectrometry detection

Qin

Jatamunua²,

Zhang

et al. 2017

Journal of Chromatography B

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Diffusion, convergence and influence of pharmaceutical innovations: a comparative study of Chinese and U.S. patents

Jiang

Luan

2018

Global Health

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BackgroundDespite the significant impact of pharmaceutical innovations on healthcare, our understanding is still limited because previous studies explored only a few cases and largely came from a linear perspective. This study presents a detailed case of the Chinese and U.S. pharmaceutical patents and investigated advancements that the global pharmaceutical industry is experiencing. A network analysis approach was used to identify certain aspects regarding the diffusion of pharmaceutical innovations, including innovation attributes, adopter characteristics, and clustering.MethodsBased on a patent database, network analysis and visualization, this study captured the structure of patent networks for the global pharmaceutical landscape in a large set of patents. A large volume of patent data, 15,422 patent filings citing Chinese pharmaceutical patents, 28,075 citing U.S. patents, and 6064 citing both Chinese and U.S. patents during 2014–2015, were retrieved from the world patent database, Derwent Innovation Index. The networks reveal many interesting features of technological innovation, convergence trends and diffusion patterns.ResultsConvergence innovations were identified, with the advantage and influence of U.S. patents shown in a variety of areas, and their Chinese counterparts were concentrated in traditional Chinese medicine. Early adopters of Chinese patents were mainly universities within the national sector, while early adopters of U.S. patents were academic institutions and large international pharmaceutical corporations of balanced quantity, contributing a higher degree of technology convergence. Technology convergence in the cancer-treatment sector is expected to have a high future development potential.ConclusionChinese and U.S. pharmaceutical innovations contributed differently to the growth and development of the global pharmaceutical industry. The findings of this study can provide rich knowledge about the influence, diffusion and convergence trends of Chinese and U.S. pharmaceutical innovations. In the pharmaceutical industry, the findings may provide implications for researchers, policy makers, health professionals, and the general public to help improve the overall health of society.

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Analysis for Science Librarians of the 2015 Nobel Prize in Physiology or Medicine: The Life and Work of William C. Campbell, Satoshi Ōmura, and Youyou Tu

Cited by 3 publications

References 28 publications

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography–tandem mass spectrometry detection

Diffusion, convergence and influence of pharmaceutical innovations: a comparative study of Chinese and U.S. patents

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