2021
DOI: 10.4269/ajtmh.20-1019
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Analysis of 262 Children with Scrub Typhus Infection: A Single-Center Experience

Abstract: Scrub typhus, a vector-borne rickettsiosis, is the leading treatable cause of non-malarial febrile illness in Asia. The myriad of typical and atypical features poses a clinical conundrum. We aimed to study the clinical and laboratory profile of children with scrub typhus infection diagnosed by IgM ELISA. Data of children < 12 years presenting with undifferentiated fever to the pediatric services of a tertiary teaching institute between January 2012 and December 2018 were retrieved. Children with seropositiv… Show more

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Cited by 15 publications
(12 citation statements)
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“…There has been a resurgence of scrub typhus across India in the recent years; and scrub typhus has re-emerged as a major cause of acute undifferentiated febrile illnesses (AUFI) with high morbidity and mortality [5,6]. This disease is known to occur in diverse ecological settings in India with large numbers of cases being reported from Tamil Nadu, Andhra Pradesh, Karnataka, and Kerala in the South, Himachal Pradesh, Uttaranchal, Jammu, and Kashmir in the North, Meghalaya, Assam, and Nagaland in the North-East, West Bengal and Bihar in the East, and Maharashtra and Rajasthan in the West [7].…”
Section: Introductionmentioning
confidence: 99%
“…There has been a resurgence of scrub typhus across India in the recent years; and scrub typhus has re-emerged as a major cause of acute undifferentiated febrile illnesses (AUFI) with high morbidity and mortality [5,6]. This disease is known to occur in diverse ecological settings in India with large numbers of cases being reported from Tamil Nadu, Andhra Pradesh, Karnataka, and Kerala in the South, Himachal Pradesh, Uttaranchal, Jammu, and Kashmir in the North, Meghalaya, Assam, and Nagaland in the North-East, West Bengal and Bihar in the East, and Maharashtra and Rajasthan in the West [7].…”
Section: Introductionmentioning
confidence: 99%
“…The hematological abnormalities identified in the current study were anemia, leukocytosis, leukopenia, thrombocytosis, thrombocytopenia, and elevated ESR, which were present in 168 (81.55%), 42 (20.39%), 14 (6.8%), 5 (2.43%), 102 (49.51%), and 157 (76.21%) cases, respectively. The percentage of anemia associated with scrub typhus reported in several studies conducted by various authors from different parts of India was between 29% and 80% [ 15 , 28 ]. Palanivel et al [ 29 ] from Chennai, India, revealed that 83% of the people they studied had anemia, which is consistent with the findings of the present study.…”
Section: Discussionmentioning
confidence: 99%
“…The ideal environment for developing infectious vectors can be found in specific niches such as grassy areas, riverbanks, and forest clearings. These restricted places, often known as scrub typhus islands, are high-risk for human populations [5]. Scrub typhus epidemiology is hampered by bacterial strains' antigenic and molecular diversity and their unclear relationship with human pathogenicity [8].…”
Section: Review Epidemiology and Distributionmentioning
confidence: 99%
“…The Western immunoblot test using sodium dodecyl sulfategel electrophoresed and electroblotted is a powerful and accurate serodiagnosis technique for seroepidemiology, and verification of serologic findings agglutinogen is suitable for large-scale monitoring. It also aids in the investigation of cross-reactive strains [5]. IFA typically employs antigens from three serotypes: Karp, Kato, and Gilliam.…”
Section: Weil-felix Testmentioning
confidence: 99%
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