Analysis of 54 Cases of Hypopigmentation and Hyperpigmentation Along the Lines of Blaschko

Nehal, Kishwer S.; PeBenito, Rhandy; Orlow, Seth J.

doi:10.1001/archderm.1996.03890340027005

Cited by 144 publications

(58 citation statements)

References 38 publications

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“…[345][346][347][348][349][350] The pattern resembles a negative image of the pigmentation seen in incontinentia pigmenti (see p. 297). [345][346][347][348][349][350] The pattern resembles a negative image of the pigmentation seen in incontinentia pigmenti (see p. 297).…”

Section: Hypomelanosis Of Itomentioning

confidence: 99%

“…They are characterized by linear, whorled, or reticulate areas of hyperpigmentation. 350 Another study in which pigmentary anomalies along the lines of Blaschko were associated with abnormalities of the central nervous system included a few patients with incontinentia pigmenti and hypomelanosis of Ito; most cases could not be categorized further. [463][464][465][466] A review of 54 children with segmental, linear, or swirled hyper-and/or hypopigmentation along the lines of Blaschko revealed that 16 had extracutaneous manifestations.…”

Section: Patterned Hypermelanosismentioning

confidence: 99%

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Disorders of pigmentation

Weedon

2010

Weedon's Skin Pathology

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Section: Hypomelanosis Of Itomentioning

confidence: 99%

Section: Patterned Hypermelanosismentioning

confidence: 99%

Disorders of pigmentation

Weedon

2010

Weedon's Skin Pathology

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“…Hyperpigmented whorls or streaks on the neck may appear according to the lines of Blaschko [4, 5]. This type of pigmentary patterning gives a clue to genetic mosaicism [6].…”

Section: Introductionmentioning

confidence: 99%

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

Itin

Lautenschläger

1998

Dermatology

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Reticulate pigmentation of the neck is a common finding in numerous genodermatoses and acquired diseases. As the neck is readily accessible to medical inspection, it may serve as a diagnostic window for various dermatoses. Several entities out of the spectrum of ectodermal dysplasia present with reticulate or mottled pigmentation on the upper trunk and neck. The most impressive genodermatoses with punctate and reticulate pigmentation affecting the neck are the Naegeli-Franceschetti-Jadassohn syndrome, dermatopathia pigmentosa reticularis and dyskeratosis congenita. Reticulate pigmented anomaly of the flexures and lentiginosis, disorders of cornification and related entities are further genodermatoses which may involve the neck. In our review we have integrated inherited dermatoses which do not obligatorily affect the neck but have been well documented to do so. Our work should give the clinician a checklist on genodermatoses which may produce reticulate and mottled pigmentation on the neck.

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“…The linear nature of the pigmented bands probably reflects the clonal migration and proliferation of embryonic melanoblasts, so somatic mosaicism that develops during embryogenesis appears to be the underlying aetiology [9]. In 1996 Nehal et al [10] studied 54 patients with both hypopigmentation and hyperpigmentation following the lines of Blaschko. It was postulated that developmental somatic mosaicism leading to proliferation and migration of two mixed populations of melanocytes with different potential for pigment production was the cause of these abnomalies.…”

Section: Discussionmentioning

confidence: 99%

Progressive Cribriform and Zosteriform Hyperpigmentation along with Vitiligo

Han¹,

Chang²

2017

JCDSA

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Background: Progressive cribriform and zosteriform hyperpigmentation (PCZH) is a disorder of pigmentation. Although several cases of PCZH have been reported, cases that associated with vitiligo have not been published in the past. Aim: We report the case to reveal the interesting mosaicism reflecting on the skin. Case Presentation: This case presents a phenomenon of the coexistence of hyperpigmentation and depigmentation arranged in unilateral and symmetric distribution in one patient. Conclusion: The aetiology of the pigmental disorders is still unknown. The linear nature of the pigmented bands probably reflects the clonal migration and proliferation of embryonic melanoblasts, so somatic mosaicism that develops during embryogenesis appears to be the underlying aetiology, which is leading to proliferation and migration of two mixed populations of melanocytes with different potential for pigment production.

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Analysis of 54 Cases of Hypopigmentation and Hyperpigmentation Along the Lines of Blaschko

Cited by 144 publications

References 38 publications

Disorders of pigmentation

Disorders of pigmentation

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

Progressive Cribriform and Zosteriform Hyperpigmentation along with Vitiligo

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