Analysis of 87 patients with Löfgren’s syndrome and the pattern of seasonality of subacute sarcoidosis

Abstract

In this study, there were differences in the amplitude of the seasonal variation by age and by gender. Well-designed prospective studies are required to better understand the importance of the findings we respect to the pathogenesis of the disease.

Seasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis

“…No studies have assessed the seasonality of Tuberculin results; however, patients with sarcoidosis are usually anergic to Tuberculin due to their poor immunity. The current study has shown that the seasonal variation in the onset of sarcoidosis symptoms in the subset of patients who were Tuberculin anergic, was comparable with that seen in the total sarcoid patient cohort 6 . These observations are important, particularly for countries in which tuberculosis is endemic and where BCG vaccination is routine, as Tuberculin anergy will parallel the activation of sarcoidosis and its seasonal variation.…”

“…Both host and environmental factors may play important roles in the aetiopathogenesis of sarcoidosis’ 2 . Seasonal variation studies are important if infective agents are involved or if a specific time period needs to be targeted for investigation of the disease 3–6 . This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in symptomatic patients with sarcoidosis.…”

“…It can be difficult or even impossible to differentiate pulmonary tuberculosis from sarcoidosis. Sarcoidosis has a well‐established seasonal variation with presentations most frequent in spring 3–5 and least frequent in summer or autumn 6 …”

Indications for performing flexible bronchoscopy: Trends over 34 years at a tertiary care hospital

“…This is in agreement with previous studies studying seasonal variability of sarcoidosis. [ 16 24 25 26 ] The increased incidence of infections and pleural effusions can be explained by the impact of the rains in the Indian subcontinent. [ 27 28 29 ] A higher incidence of tuberculosis was seen in spring and summer months in a review of several studies similar to our experience.…”

Acute Form of Sarcoidosis: Löfgren’s Syndrome

“…The syndrome is rare between young children and teenagers and elder people over the age of 70 [13]. Females are three times more likely to have Löfgren's syndrome than males [14], significantly frequent in springtime compared to wintertime [15]. Past studies suggest, that environmental, occupational factors, contacts with dust or chemicals may trigger the disease [16].…”