Seasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis

Demirkok, Sevtap Sipahi; Başaranoğlu, Metin; Çoker, Elif; Karayel, Tuncer

doi:10.1111/j.1440-1843.2007.01062.x

Cited by 27 publications

(16 citation statements)

References 13 publications

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“…peripheral anergy is typically confi ned to those with active sarcoidosis and is shown to be a sensitive and specifi c marker of disease acitivity. 43 In keeping with previous reports, patients with active pulmonary sarcoidosis exhibited peripheral anergy to mycobacterial (primarily TLR2) antigens 44,45 and TLR9 ligands 46 ( Figs 5A, 5B ). Mycobacterial antigens are of particular interest, as investigations have confi rmed their presence in diseased sarcoidosis tissue, 47 presumably relating to impaired antigen clearance, 48 and it is not alter the expression of a 7 nAChR, suggesting that tachyphylaxis relating to changes in receptor density did not occur.…”

Section: Peripheral Anergy To Specifi C Tlr Ligands In Symptomatic Pasupporting

confidence: 84%

Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis

Julián

Shao

Schlesinger

et al. 2013

Chest

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Section: Peripheral Anergy To Specifi C Tlr Ligands In Symptomatic Pasupporting

confidence: 84%

Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis

Julián

Shao

Schlesinger

et al. 2013

Chest

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“…For example, the highest incidence of sarcoidosis was observed in the winter in Olmsted County, MN [18] while a study from India observed the highest incidence in the summer and the lowest incidence in the winter [19]. Another study from Turkey observed the peak incidence in the spring [20]. Possible explanations for the geographic variation include different environmental exposures and availability of sunlight [3, 18, 20].…”

Section: Discussionmentioning

confidence: 99%

Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study

Ungprasert

Crowson

Matteson

2016

Respiratory Medicine

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Background Smoking and obesity might alter the risk of sarcoidosis. However, the data remained inconclusive. Methods A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified based on individual medical record review. For each sarcoidosis subject, one sex and aged-matched control without sarcoidosis was randomly selected from the same underlying population. Medical records of cases and controls were reviewed for smoking status at index date and body mass index (BMI) within 1 year before to 3 months after index date. Results 345 incident cases of sarcoidosis and 345 controls were identified. The odds ratio of sarcoidosis comparing current smokers with never smokers adjusted for age and sex was 0.34 (95% confidence interval (CI), 0.23 – 0.50). The odds ratio of sarcoidosis comparing current smokers with never smokers and former smokers adjusted for age and sex was 0.38 (95% CI, 0.26 – 0.56). The odds ratio of sarcoidosis comparing overweight subjects (BMI > 25 kg/m2 but < 30 kg/m2) with subjects with normal/low BMI was 1.12 (95% CI, 0.72 – 1.75). The odds ratio of sarcoidosis comparing obese subjects (BMI > 30 kg/m2) with subjects with normal/low BMI was 2.54 (95% CI, 1.58 – 4.06). The odds ratio of sarcoidosis comparing obese subjects with non-obese subjects was 2.38 (95% CI, 1.60 – 3.56). Conclusion In this population, current smokers have a lower risk of developing sarcoidosis while subjects with obesity have a higher risk of developing sarcoidosis.

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“…However, previous studies on the seasonality of sarcoidosis have yielded conflicting results. [1][2][3][4][5] …”

Section: Introductionmentioning

confidence: 99%

Seasonal variation in incidence of sarcoidosis: a population-based study, 1976–2013

Ungprasert

Crowson

Matteson

2016

Thorax

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Studies of seasonal patterns of incidence of sarcoidosis may provide a better understanding of potential environmental triggers of the disease. In this study, Olmsted County, Minnesota residents who were diagnosed with sarcoidosis between 1976 and 2013 were identified based on individual medical record review. The seasonal variation of incident sarcoidosis was then calculated. The age and sex adjusted incidence rate of sarcoidosis was lower in autumn (2.0/100,000; 95% CI 1.5–2.5) compared with winter (3.2/100,000; 95% CI 2.6–3.8), spring (2.8/100,000; 95% CI 2.2–3.4) and summer (2.9/100,000; 95% CI 2.2–3.5; p=0.024). Subgroup analysis per decade consistently showed lower incidence of sarcoidosis in the autumn.

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Seasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis

Cited by 27 publications

References 13 publications

Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis

Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis

Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study

Seasonal variation in incidence of sarcoidosis: a population-based study, 1976–2013

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