Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study

Ungprasert, Patompong; Crowson, Cynthia S.; Matteson, Eric L.

doi:10.1016/j.rmed.2016.10.003

Cited by 75 publications

(58 citation statements)

References 19 publications

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“…Obesity is a well-recognized risk factor for almost all comorbidities included in this study, particularly cardiovascular disease, diabetes mellitus, hyperlipidemia and hypertension 34 . Interestingly, obesity has been found to be a risk factor for sarcoidosis in a large cohort study of African-American females 35 and a higher prevalence of obesity of patients with sarcoidosis than comparators was observed in this cohort 36 .…”

Section: Discussionmentioning

confidence: 58%

Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013

Ungprasert¹,

Matteson²,

Crowson³

2017

Mayo Clinic Proceedings

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Objective To evaluate the risk and pattern of multimorbidity in patients with sarcoidosis. Methods A cohort of Olmsted County, Minnesota residents first diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified through the medical record-linkage system of the Rochester Epidemiology Project. Diagnosis was verified based on individual medical record review. A cohort of sex and age-matched comparators without sarcoidosis was assembled from the same population. Data on 18 chronic conditions recommended by the United States Department of Health and Human Services for both cases and comparators were retrieved and compared. Results The prevalence of multimorbidity (i.e., the presence of 2 or more chronic conditions) was similar between the 2 groups (111/345 cases and 110/345 comparator, P=.99). After index date, 156 cases and 142 comparators developed multimorbidity, corresponding to HR of 1.60 (95% CI, 1.27 – 2.01; P<.001). The cumulative incidence of the presence of ≥ 3, 4 and 5 chronic conditions was also consistently significantly higher among cases than comparators. Analysis by specific type of chronic condition revealed a significantly higher cumulative incidence of coronary artery disease, congestive heart failure, arrhythmia, stroke/transient ischemic attack, arthritis, depression, diabetes and major osteoporotic fracture. Conclusion In this population, patients with sarcoidosis had a significantly higher risk of developing multimorbidity compared with sex and age-matched subjects without sarcoidosis.

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Section: Discussionmentioning

confidence: 58%

Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013

Ungprasert¹,

Matteson²,

Crowson³

2017

Mayo Clinic Proceedings

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“…47 The latter might be the reason why incidence and/or severity of some inflammatory diseases have been reported to be reduced in smokers. [56][57][58] Nicotine, the main immunosuppressive constituent of cigarette smoke, has even been suggested as a potential therapeutic agent in chronic inflammatory diseases such as dermatitis and ulcerative colitis. 59,60 As an epidemiological survey, the study has several limitations that need to be critically addressed.…”

Section: F I G U R Ementioning

confidence: 99%

To what extent does smoking affect gingival bleeding response to supragingival plaque? Site‐specific analyses in a population‐based study

Holde

Jönsson

Oscarson

et al. 2019

J of Periodontal Research

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Background and objective The aim of this study was to investigate the influence of smoking on the site‐specific association between bleeding on gingival probing and supragingival plaque and to assess whether this differs in different regions of the dentition. Methods Data from a representative sample of 1911 adults (20‐79 years old) in Northern Norway were analyzed. Periodontal examinations consisted of full‐mouth recordings of periodontal probing depth (PD), bleeding on probing (BOP), and presence of supragingival plaque. Smoking status and background characteristics were self‐reported by questionnaire. The association between plaque and BOP was assessed in several three‐level (subject, tooth, and site) random intercept logistic regression models adjusted for PD, smoking status, socioeconomic factors, and body mass index. In a further model, it was assessed whether the association between supragingival plaque and BOP differed in different parts of the dentition. Results For plaque‐free sites, bleeding tendency was lower in smokers, the odds ratio (OR) was 0.773 with a 95% confidence interval of 0.678‐0.881 as compared to non‐smokers (OR: 1; ref., P < .001). The odds of BOP at plaque‐covered sites in non‐smokers were increased twofold (OR: 2.117; 2.059‐2.177). Albeit bleeding tendency was slightly increased in plaque‐covered sites in smokers, it was considerably lower as compared to plaque‐covered sites in non‐smokers (OR: 1.459; 1.282‐1.662, P < .001). Smoking ≥ 20 pack‐years further attenuated the association. In smokers, the odds of BOP were reduced in all parts of the dentition, lower and upper anterior and posterior teeth (χfalse(4false)2= 32.043, P < .001). When restricting the data to younger adults (20‐34 year old), smoking had only a slight effect on the association between plaque and BOP. For plaque‐free and plaque‐covered sites, differences in ORs were not statistically noticeable (P = .221 and P = .235, respectively). Conclusions Smoking considerably attenuates the site‐specific association between plaque and BOP with a dose‐dependent effect. The effect of smoking did not differ across tooth types.

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“…The odds of developing sarcoidosis were about 2.4 times higher among obese subjects (i.e., body mass index > 30 kg/m 2 ) compared to those who were not obese (17). While certainly speculative, this observation may suggest the role of leptin, a hormone secreted by adipocytes, in the pathogenesis of sarcoidosis.…”

Section: Epidemiology Of Sarcoidosismentioning

confidence: 98%

“…The odds ratio of sarcoidosis comparing current smokers with never smokers and former smokers adjusted for age and sex was 0.38 (17). This is an interesting observation, as smoking is generally associated with a higher risk of pulmonary disease, such as chronic obstructive pulmonary disease and lung cancer.…”

Section: Epidemiology Of Sarcoidosismentioning

confidence: 99%

Epidemiology and clinical characteristics of sarcoidosis: an update from a population-based cohort study from Olmsted County, Minnesota

2017

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Summary Information about the epidemiology, clinical manifestations and comorbidities of sarcoidosis among Caucasians is relatively scarce. This review focuses primarily on the data from a recently published Caucasian-predominant population-based cohort from Olmsted County, Minnesota. Overall, the incidence rate was 10.0 per 100,000 population, which suggested that sarcoidosis is less common in Caucasians than in Blacks, but is more common in Caucasians than in Asians. Intrathoracic involvement was seen in the vast majority of patients, but less than half have respiratory symptoms. The most common extra-thoracic manifestations were skin rash followed by arthralgia, ophthalmologic involvement, hepatic involvement, splenomegaly, renal involvement, neurological involvement, extra-thoracic lymphadenopathy, exocrine gland involvement, upper respiratory tract involvement and cardiac involvement. Compared to sex and age-matched subjects, patients with sarcoidosis suffer from increased rates of cardiovascular disease, venous thromboembolism and hospitalized infection.

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Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study

Cited by 75 publications

References 19 publications

Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013

Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013

To what extent does smoking affect gingival bleeding response to supragingival plaque? Site‐specific analyses in a population‐based study

Epidemiology and clinical characteristics of sarcoidosis: an update from a population-based cohort study from Olmsted County, Minnesota

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