Analysis of a Two-Stage Fermentor With Recycle for Continuous Ethanol Production

Nishiwaki, Akio; Dunn, Irving J.

doi:10.1080/00986449808912715

Cited by 17 publications

(12 citation statements)

References 19 publications

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“…In order to achieve higher ethanol productivity, many researchers [74][75][76][77][78][79] ) was obtained with complete conversion of glucose to ethanol in the two-stage system. Bai et al [79] observed high fluctuations in fermentation parameters in three tubular bioreactors arranged in series (Fig.…”

Section: Two-stage Bioreactor With Recycling For Continuous Ethanol Pmentioning

confidence: 99%

“…The kinetic parameters were obtained for a continuous glucose-to-ethanol fermentation with Saccharomyces cerevisiae in recycling of cells using the membrane fermenter by Groot [74][75][76][77].…”

Section: Two-stage Bioreactor With Recycling For Continuous Ethanol Pmentioning

confidence: 99%

“…The liquid stream that moves from Figure 1. Two-stage fermenter with cell recyling at each stage [74].…”

Section: Two-stage Bioreactor With Recycling For Continuous Ethanol Pmentioning

confidence: 99%

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Recent Advances in Production of Bioethanol from Lignocellulosic Biomass

et al. 2009

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Ethanol is considered the most potential next generation automotive fuel because it is carbon-neutral and could be produced from renewable resources like lignocellulosic biomass. There are some technological barriers such as pretreatment, saccharification of cellulose and hemicellulose matrix, and simultaneous fermentation of hexose and pentose sugars which needs to be addressed for efficient conversion of lignocellulosic biomass to bioethanol. This paper reviews the various process options and kinetic models adopted towards resolving the technological challenges to develop a low-cost commercial process.

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Section: Two-stage Bioreactor With Recycling For Continuous Ethanol Pmentioning

confidence: 99%

Section: Two-stage Bioreactor With Recycling For Continuous Ethanol Pmentioning

confidence: 99%

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Recent Advances in Production of Bioethanol from Lignocellulosic Biomass

et al. 2009

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“…With a microfiltration system, Groot et al [5] demonstrated that the ethanol productivity could be increased to 55 g l À1 h À1 with concomitant ethanol and glucose concentrations of 53 and 183 g l À1 , respectively. However, due to (1) the inhibitory effect of the ethanol concentration on the yeast growth and ethanol production, and (2) the uncoupling between growth and ethanol production above high ethanol concentration, theoretical approaches [8,9] showed that recycle twostage continuous fermentations with membrane separator would be potentially the most efficient system for improving ethanol productivity. In these numerical works, the proposed configuration was a first stage dedicated to cell growth and a second stage to ethanol production in a bioreactor coupled to an external membrane module in order to reach high cell density.…”

Section: Introductionmentioning

confidence: 99%

“…In these numerical works, the proposed configuration was a first stage dedicated to cell growth and a second stage to ethanol production in a bioreactor coupled to an external membrane module in order to reach high cell density. Nishiwaki and Dunn [8,9] demonstrated numerically that this system was more efficient than either a recycle chemostat or a two-stage bioreactor with a single separator after the final stage. At the optimum dilution rate, Nishiwaki and Dunn demonstrated numerically that for the two-stage reactor with membrane ultrafiltration, the ethanol productivity and the substrate conversion were higher than for the other configurations.…”

Section: Introductionmentioning

confidence: 99%

Very high ethanol productivity in an innovative continuous two-stage bioreactor with cell recycle

Chaabane

Aldiguier

Alfenore³

et al. 2006

Bioprocess Biosyst Eng

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The performance of an innovative two-stage continuous bioreactor with cell recycle-potentially capable of giving very high ethanol productivity-was investigated. The first stage was dedicated to cell growth, whereas the second stage was dedicated to ethanol production. A high cell density was obtained by an ultrafiltration module coupled to the outlet of the second reactor. A recycle loop from the second stage to the first one was tested to improve cell viability and activity. Cultivations of Saccharomyces cerevisiae in mineral medium on glucose were performed at 30 degrees Celsius and pH 4. At steady state, total biomass concentrations of 59 and 157 gDCW l(-1) and ethanol concentrations of 31 and 65 g l(-1) were obtained in the first and second stage, respectively. The residual glucose concentration was 73 g l(-1) in the first stage and close to zero in the second stage. The present study shows that a very high ethanol productivity (up to 41 g l(-1) h(-1)) can indeed be obtained with complete conversion of the glucose and with a high ethanol titre (8.3 degrees GL) in the two-stage system.

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Strain improvement of industrially important microorganisms based on resistance to toxic metabolites and abiotic stress

2017

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Improvement of the biosynthetic capabilities of industrially relevant microbes to produce desired metabolites in higher quantities is one of the important topics of modern biotechnology. In this article, different strategies of improvement of mutated microbial strains are briefly described. This is followed by the first comprehensive review of the literature on obtaining high yielding microorganisms, that is, mutants exhibiting resistance to antimetabolites, nutritional repression, and abiotic stresses as well as tolerance to solvents and toxic substrates or products. Furthermore, the efficiency of the microbial metabolites produced by improved microbial strains, advantages, and limitations, as well as future prospects for strategies of strain development are discussed.

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Analysis of a Two-Stage Fermentor With Recycle for Continuous Ethanol Production

Cited by 17 publications

References 19 publications

Recent Advances in Production of Bioethanol from Lignocellulosic Biomass

Recent Advances in Production of Bioethanol from Lignocellulosic Biomass

Very high ethanol productivity in an innovative continuous two-stage bioreactor with cell recycle

Strain improvement of industrially important microorganisms based on resistance to toxic metabolites and abiotic stress

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