Analysis of amantadine in biological fluids using hollow fiber-based liquid–liquid–liquid microextraction followed by corona discharge ion mobility spectrometry

Saraji, Mohammad; Khayamian, Taghi; Mirmahdieh, Shiva; Bidgoli, Ali Akbar Hajialiakbari

doi:10.1016/j.jchromb.2011.09.017

Cited by 15 publications

(8 citation statements)

References 40 publications

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“…For example, amantadine is utilized as an antiviral medicine for influenza [30] and as an anti-Parkinson agent [31]. For the determination of amantadine in biological samples, chromatography (HPLC-MS and GC-FID) or spectroscopy (ion mobility spectrometry and fluorescence) with obligatory derivatization and/or extraction steps are used [32][33][34][35][36].…”

Section: Quantification Of Purity Of Reference Compoundsmentioning

confidence: 99%

Determination of the purity of pharmaceutical reference materials by 1 H NMR using the standardless PULCON methodology

Monakhova

Kohl-Himmelseher

Kuballa

et al. 2014

Journal of Pharmaceutical and Biomedical Analysis

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Section: Quantification Of Purity Of Reference Compoundsmentioning

confidence: 99%

Determination of the purity of pharmaceutical reference materials by 1 H NMR using the standardless PULCON methodology

Monakhova

Kohl-Himmelseher

Kuballa

et al. 2014

Journal of Pharmaceutical and Biomedical Analysis

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“…Also, the same group developed a method based on LLLME combined with corona discharge ion mobility spectrometry for the analysis of amantadine in human plasma samples (Saraji et al ., 2011a–c). Amantadine was extracted through a thin phase of organic solvent ( n ‐dodecane) filling the pores of the hollow fiber wall and then back‐extracted into the organic acceptor phase (methanol) located in the lumen of the hollow fiber.…”

Section: Hollow Fiber Based Liquid‐phase Microextractionmentioning

confidence: 99%

Microextraction techniques in therapeutic drug monitoring

Farhadi

Hatami

Matin

2012

Biomedical Chromatography

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Therapeutic drug monitoring (TDM), as part of clinical process of medical treatments, is commonly used to maintain 'therapeutic' drug concentrations. TDM is useful to identify the causes of unwanted or unexpected responses, to prevent unnecessary diagnostic testing, to improve clinical outcomes, and even to save lives. The determination of drug concentration in blood samples requires an excellent sample preparation procedure. Recent trends in sample preparation include miniaturization, automation, high-throughput performance, on-line coupling with analytical instruments and low-cost operation through extremely low or no solvent consumption. Microextraction techniques, such as liquid- and solid-phase microextraction, have these advantages over the traditional techniques. This paper reviews the recent developments in microextraction techniques used for drug monitoring in serum, plasma or blood samples.

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“…Literature of the last two decades reveals several analytical methods for the determination of AMD in animal tissues [8] , [9] , [10] , [11] , [12] , [13] , [14] , biological fluids like plasma [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] and urine [22] , [23] and also in processed food samples [14] . These methods have utilized different analytical techniques like spectrophotometry [19] , capillary electrophoresis [15] , immunochromatography [13] , micellar electrokinetic chromatography [21] , ion mobility spectrometry [22] , gas chromatography with flame ionization detector [23] , high performance liquid chromatography (HPLC) with ultraviolet [18] and fluorescence detection [16] , liquid chromatography-tandem mass spectrometry (LC–MS/MS) [14] , [17] , [20] , ultra performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) [9] , [10] , [11] , [12] and ultra high performance liquid chromatography coupled to high resolution LTQ orbitrap mass spectrometry [8] . However, as AMD does not possess any chromophoric group, a majority of these methods require prior derivatization for sample preparation which is tedious, cumbersome and time consuming.…”

Section: Introductionmentioning

confidence: 99%

“…However, as AMD does not possess any chromophoric group, a majority of these methods require prior derivatization for sample preparation which is tedious, cumbersome and time consuming. Only three methods have analyzed AMD without derivatization in human plasma with a sensitivity of 3.9 ng/mL [17] and 20 ng/mL [20] , [22] respectively. Moreover, the chromatographic analysis time was ≥ 3.5 min in these methods.…”

Section: Introductionmentioning

confidence: 99%

Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study

Bhadoriya¹,

Rathnam²,

Dasandi³

et al. 2018

Journal of Pharmaceutical Analysis

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A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for reliable estimation of amantadine (AMD), an antiviral drug in human plasma. The analyte and internal standard (IS), amantadine-d6 (AMD-d6), were extracted from 200 µL plasma by solid phase extraction on Phenomenex Strata-X-C 33 µ cartridges. Chromatography was performed on Synergi™ Hydro-RP C18 (150 mm × 4.6 mm, 4 µm) analytical column using a mixture of acetonitrile and 10 mM ammonium formate, pH 3.0 (80:20, v/v) as the mobile phase. Detection and quantitation was done by multiple reaction monitoring in the positive ionization mode for AMD (m/z 152.1 → 135.1) and IS (m/z 158.0 → 141.1) on a triple quadrupole mass spectrometer. The assay was linear in the concentration range of 0.50–500 ng/mL with correlation coefficient (r2) ≥ 0.9969. The limit of detection of the method was 0.18 ng/mL. The intra-batch and inter-batch precisions were ≤ 5.42% and the accuracy varied from 98.47% to 105.72%. The extraction recovery of amantadine was precise and quantitative in the range of 97.89%–100.28%. IS-normalized matrix factors for amantadine varied from 0.981 to 1.012. The stability of AMD in whole blood and plasma was evaluated under different conditions. The developed method was successfully applied for a bioequivalence study with 100 mg of AMD in 32 healthy volunteers. The reproducibility of the assay was determined by reanalysis of 134 subject samples.

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Analysis of amantadine in biological fluids using hollow fiber-based liquid–liquid–liquid microextraction followed by corona discharge ion mobility spectrometry

Cited by 15 publications

References 40 publications

Determination of the purity of pharmaceutical reference materials by 1 H NMR using the standardless PULCON methodology

Determination of the purity of pharmaceutical reference materials by 1 H NMR using the standardless PULCON methodology

Microextraction techniques in therapeutic drug monitoring

Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study

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