Analysis of anti-microbial and anti-biofilm activity of hand washes and sanitizers against P. aeruginosa and S. aureus

Kettab, Ahmed; Ahmed, Husham M.; Ahmed, Fasih Ali; Ali, Alisha Akbar; Akbar, Jehangir; Rana, Junaid; Tariq, Uroosa; Abidi, Syed Hani

doi:10.5455/jpma.2776

Cited by 7 publications

(10 citation statements)

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“…In one of our previous studies, the methanolic extract of the plant and its fractions in various solvents showed remarkable alpha‐amylase inhibitory activities (against the enzyme obtained Aspergillus oryzae and urease inhibitory activities (against the enzyme of Jack Bean origin), which were equivalent to the standards . The plant also exhibited notable antioxidant activity …”

Section: Introductionmentioning

confidence: 99%

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Study of Phytochemicals of Melilotus indicus and Alpha‐Amylase and Lipase Inhibitory Activities of Its Methanolic Extract and Fractions in Different Solvents

2019

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Melilotus indicus is used for food and medicinal purposes. The present study aimed to explore its phytochemicals and antidiabetic and anti-obesity potential. Methanolic extract (ME) of the dried, ground herb, obtained by the Soxhlet method, was fractionated into hexane, chloroform, ethyl acetate, 1butanolic and aqueous fractions. Chromatographic techniques were used for further fractionation. The compounds identified by GC-MS included 3-O-methyl-D-glucose, 3-hydroxyspirost-8en-11-one, 1-phenanthrenecarboxylic acid-tetradecahydro-7-(2methoxy-2-oxoethylidene)-1,4a,8-triethyl-9-oxo-methylester, 3-(1-methylhept-1-enyl)-5-methyl-2,5-dihydrofuran-2-one, squalene, phytol, 4-(4-hydroxy-2,6,6-trimethyl-7-oxabicyclo[4.1.0] hept-1-yl-3-buten-2-one, 2,4-bis(1,1-dimethylethyl)phenol, geranyl isovalerate and thymol. The ME and its fractions displayed porcine pancreatic alpha-amylase inhibitory activity higher than Acarbose. Interestingly, they promoted the lipase activity showing opposite trend to that Orlistat. The plant may be used to control diabetes and in the in the promotion of lipase action.

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Section: Introductionmentioning

confidence: 99%

“…The compounds reported from M. indicus include scopoletin, umbeliferone, herniarin, fraxidin, 3,4‐dihydrocoumarin, hexadecanal, p ‐isopropylanisole and thymol . The plant has been found to have considerable flavonoid and phenolic contents …”

Section: Introductionmentioning

confidence: 99%

Study of Phytochemicals of Melilotus indicus and Alpha‐Amylase and Lipase Inhibitory Activities of Its Methanolic Extract and Fractions in Different Solvents

2019

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“…It is widely and practically acceptable more in hospitals and clinical settings. 14 Table 1 shows the effectiveness of different hand sanitizers on various groups but none of the research works support that the hand sanitizer should be used on soiled or greasy hands. [15][16][17] The hand sanitizer should be used in those conditions where there is no availability of soap and water, which can offer a short-term solution.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Ahmed K et al 14 The antimicrobial activity of commonlyused hand-washes and sanitizers were assessed using agar well diffusion method, while the anti-biofilm activity of the handwashes and sanitizers was qualitatively assessed using the air-liquid interface covers lip as say. All hand sanitizer products sampled listed ethanol or isopropyl alcohol as its active ingredient either in single form or in combination with other compounds.…”

Section: Discussionmentioning

confidence: 99%

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Hand Sanitizer an Alternative to Hand Washing—A Review of Literature

Singh

Potlia

Malhotra

et al. 2020

Journal of Advanced Oral Research

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Aim: COVID-19 is a new illness and a big threat to global health. No specific antiviral agents are available for its treatment. The finest approach to manage this threat is to clean our hands properly. Washing hands under running water is a better way to stop the spread of infections than using a hand sanitizer. The aim of the study is to show that washing hands is efficacious than using a dab of alcohol-based hand sanitizer. Materials and methods: A search was performed using three databases, PubMed, Scopus, and Google Scholar published from 2010 to 2019. The keywords for the survey were “hand-washing,” “hand sanitizer,” and “effective.” After the relevant articles were found, the critical appraisal was made to select those that were suitable for the systematic review. The inclusion criteria of the study were surveys, clinical studies, no sample size restrictions, and only English papers. Any conference abstracts, case reports, and unpublished data were excluded from this study. Results: On the basis of the keywords, 22 relevant articles were found, and of those, 17 articles were selected for the systematic review. Conclusion: This study evaluated that washing hands with soap and water are more practical and efficacious than using the sanitizer on greasy and soiled hands. An alcohol-based sanitizer, if used correctly and in appropriate volume, can disseminate certain type of micro-organisms.

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A comparative in-vitro study on antimicrobial efficacy of on-market alcohol-based hand washing sanitizers towards combating microbes and its application in combating Covid-19 global outbreak

Vuai

Sahini

Sule

et al. 2022

Heliyon

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Analysis of anti-microbial and anti-biofilm activity of hand washes and sanitizers against P. aeruginosa and S. aureus

Cited by 7 publications

References 0 publications

Study of Phytochemicals of Melilotus indicus and Alpha‐Amylase and Lipase Inhibitory Activities of Its Methanolic Extract and Fractions in Different Solvents

Study of Phytochemicals of Melilotus indicus and Alpha‐Amylase and Lipase Inhibitory Activities of Its Methanolic Extract and Fractions in Different Solvents

Hand Sanitizer an Alternative to Hand Washing—A Review of Literature

A comparative in-vitro study on antimicrobial efficacy of on-market alcohol-based hand washing sanitizers towards combating microbes and its application in combating Covid-19 global outbreak

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