The thermal management of a system needs an accurate and efficient measurement of exergy. For optimal performance, entropy should be minimized. This study explores the enhancement of the thermal exchange and entropy in the stream of Eyring–Powell fluid comprising nanoparticles saturating the vertical oriented dual cylindrical domain with uniform thermal conductivity and viscous dissipation effects. A symmetrical sine wave over the walls is used to induce the flow. The mathematical treatment for the conservation laws are described by a set of PDEs, which are, later on, converted to ordinary differential equations by homotopy deformations and then evaluated on the Mathematica software tool. The expression of the pressure rise term has been handled numerically by using numerical integration by Mathematica through the algorithm of the Newton–Cotes formula. The impact of the various factors on velocity, heat, entropy profile, and the Bejan number are elaborated pictorially and tabularly. The entropy generation is enhanced with the variation of viscous dissipation but reduced in the case of the concentration parameter, but viscous dissipation reveals opposite findings for the Newtonian fluid. From the abovementioned detailed discussion, it can be concluded that Eyring–Powell shows the difference in behavior in the entropy generation and in the presence of nanoparticles due to the significant dissipation effects, and also, it travels faster than the viscous fluid. A comparison between the Eyring-Powell and Newtonian fluid are also made for each pertinent parameter through special cases. This study may be applicable for cancer therapy in biomedicine by nanofluid characteristics in various drugs considered as a non-Newtonian fluid.