Analysis of biochemical laboratory values to determine etiology and prognosis in patients with subarachnoid hemorrhage: a clinical study

Öğden, Mustafa; Bakar, Bülent; Karagedik, Mustafa İlker; Bulut, İbrahim Umud; Cetin, Cansel; Aydın, Gülçin; Kısa, Üçler; Özveren, Mehmet Faik

doi:10.1080/01616412.2018.1545414

Cited by 12 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In acute brain injury, including out of hospital cardiac arrest, lymphopenia appears to happen frequently and is associated with poor outcome 19 ; in sine materia SAH patients, a low absolute lymphocyte count has been suggested as a potential predictor of poor outcome. 20 However, in our study lymphopenia was neither independently associated with unfavorable outcome nor with mortality. The occurrence of other complications and a more severe clinical status on admission might play a more relevant role in patient outcomes than secondary immunosuppression, which would explain our results.…”

Section: Discussioncontrasting

confidence: 80%

Section: Discussioncontrasting

confidence: 68%

See 1 more Smart Citation

Early Lymphopenia and Infections in Nontraumatic Subarachnoid Hemorrhage Patients

Attanasio¹,

Grimaldi²,

Ramiz³

et al. 2020

Journal of Neurosurgical Anesthesiology

View full text Add to dashboard Cite

Introduction: Subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. A certain degree of immunodepression has been reported during critical illness, and lymphopenia identified as an independent predictor of poor outcome; no data are available for critically ill SAH patients. We aimed to evaluate the prevalence of lymphopenia among SAH patients and its association with hospital-acquired infection.Methods: Retrospective cohort study of adult patients admitted to an intensive care unit with nontraumatic SAH between January 2011 and May 2016. Lymphocyte count was obtained daily for the first 5 days; lymphopenia was defined as lymphocyte count <1000/mm 3 . The occurrence of infection during the first 21 days after hospital admission, hospital mortality, and unfavorable neurological outcome (Glasgow Outcome Scale score 1 to 3 at 3 mo) were recorded.Results: Data from 270 patients were analyzed (median age 54 y; male 45%); 121 (45%) patients had lymphopenia and 62 (23%) patients developed infections. Median (25th to 75th percentiles) lymphocyte count at hospital admission was 1280 (890 to 1977)/mm 3 . Lymphopenia patients had more episodes of infection (38/121, 31% vs. 24/139, 17%; P = 0.003) than nonlymphopenia patients, while mortality and unfavorable outcome were similar. Lymphopenia was not independently associated with the development of infection, unfavorable neurological outcome or with mortality.Conclusions: Early lymphopenia is common after SAH, but is not significantly associated with the development of infections or with poor outcome.

show abstract

Section: Discussioncontrasting

confidence: 80%

Section: Discussioncontrasting

confidence: 68%

Early Lymphopenia and Infections in Nontraumatic Subarachnoid Hemorrhage Patients

Attanasio¹,

Grimaldi²,

Ramiz³

et al. 2020

Journal of Neurosurgical Anesthesiology

View full text Add to dashboard Cite

show abstract

“…Furthermore, systematic and quantitative analyses of relevant clinical studies are needed to explore different levels and trends of NLR in multiple diseases, which could develop potential and guiding clinical applications. Ogden et al studied patients in the neonatal intensive care unit (NICU) and found that the NLR was higher in aSAH than in traumatic subarachnoid hemorrhage ( 78 ). Eryigit et al also found that the NLR can be used in distinguishing aSAH and migraine, with different levels and changes of NLR ( 122 ).…”

Section: Practice Prospectsmentioning

confidence: 99%

The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage

et al. 2021

View full text Add to dashboard Cite

Aneurysmal subarachnoid hemorrhage (aSAH) is an important type of stroke with the highest rates of mortality and disability. Recent evidence indicates that neuroinflammation plays a critical role in both early brain injury and delayed neural deterioration after aSAH, contributing to unfavorable outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a peripheral biomarker that conveys information about the inflammatory burden in terms of both innate and adaptive immunity. This review summarizes relevant studies that associate the NLR with aSAH to evaluate whether the NLR can predict outcomes and serve as an effective biomarker for clinical management. We found that increased NLR is valuable in predicting the clinical outcome of aSAH patients and is related to the risk of complications such as delayed cerebral ischemia (DCI) or rebleeding. Combined with other indicators, the NLR provides improved accuracy for predicting prognosis to stratify patients into different risk categories. The underlying pathophysiology is highlighted to identify new potential targets for neuroprotection and to develop novel therapeutic strategies.

show abstract

“…Subsequently, activation of microglia and macrophage can lead to a widespread inflammatory cascade (8,9). In prior studies with aSAH, WBC derives and high-sensitivity C-reactive protein (hsCRP) have been investigated as blood markers reflecting systemic inflammation (10)(11)(12). It is known that elevated leukocyte count is associated with a higher risk of symptomatic vasospasm and that increased hsCRP is a predictor of secondary deterioration in patients with good-grade aSAH (13,14).…”

Section: Introductionmentioning

confidence: 99%

Clinical relevance of serum procalcitonin in patients with aneurysmal subarachnoid hemorrhage

Kim

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

Cerebral vasospasm (CV), which is closely related to the prognosis of aneurysmal subarachnoid hemorrhage (aSAH), is known to be related to an inflammatory reaction. The aim of the present study was to investigate predictable values of procalcitonin (PCT) for systemic infection and the development of CV in patients with aSAH. Patients who underwent endovascular treatment for aSAH were retrospectively enrolled. Receiver operating characteristic curve analysis was performed to evaluate the predicable value of PCT for systemic infection and CV in patients with aSAH. To clarify the association of PCT and CV, additional subgroup analysis was performed for patients without systemic infection. Multivariate logistic regression was used to explore the associations of PCT and the development of CV. A total of 374 patients with aSAH were enrolled. Of them, 164 (43.9%) had systemic infection. Optimal cutoff value of PCT for systemic infection was 0.21 ng/ml (P<0.001). In subgroup analysis of 210 patients without infection, 0.09 ng/ml of PCT level was defined as the optimal cutoff value for predicting CV after aSAH (P<0.001). In multivariate logistic regression analysis, PCT was a significant predicting factor for CV (odds ratio, 1.82; 95% confidence interval, 1.42-2.96; P=0.015). Overall, PCT had predictable value for systemic infection and the development of CV in patients who underwent endovascular treatment for aSAH. Further studies are needed to validate our results and establish its clinical applicability.

show abstract

Analysis of biochemical laboratory values to determine etiology and prognosis in patients with subarachnoid hemorrhage: a clinical study

Cited by 12 publications

References 16 publications

Early Lymphopenia and Infections in Nontraumatic Subarachnoid Hemorrhage Patients

Early Lymphopenia and Infections in Nontraumatic Subarachnoid Hemorrhage Patients

The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage

Clinical relevance of serum procalcitonin in patients with aneurysmal subarachnoid hemorrhage

Contact Info

Product

Resources

About