Analysis of breast cosmetic effects 3 years after breast‐conserving surgery and intraoperative radiotherapy with and without adjuvant whole breast irradiation

Abstract

Introduction: Intraoperative radiotherapy (IORT) based on low-kV photons may be an option for early breast cancer patients. Following Targit trial results some of those patients should undergo whole breast irradiation (WBRT) additionally. Material and methods:Since April 2010, IORT has been applied to early breast cancer patients. One hundred and fifty patients were prospectively followed up and examined to evaluate the side effects (pain, fibrosis, breast edema, telangiectasias). We present the results 3 years post-treatment. WBRT was given to 82 (54.7%) patients. Results:Tumor cavity fibrosis grade II and more was observed in 18 (12%) patients, as grade III only in 2 (1.33%) patients. Breast tissue fibrosis outside tumor cavity grade II was observed only in 2 (1.33%) patients. Breast edema was present in 10 (6.66%) patients. WBRT administration led to increased frequency of higher grade tumor cavity fibrosis (P < .0001), breast fibrosis (P < .0001), breast edema (P = .003), and occurrence of telangiectasias (P = .03), with no influence on pain reported by patients.In case of WBRT, tumor location (P = .026) and size of the irradiated breast (P = .015) were independent risk factors for higher degree of breast fibrosis, as seroma evacuation 6 months post-WBRT (P = .036) was the only independent risk factor for higher level of tumor cavity fibrosis in multiple regression. Conclusions:The cosmetic result after IORT is good and comparable to other accelerated partial breast irradiation techniques. Administration of WBRT post-IORT in breast cancer patients increases the level of fibrotic changes, breast edema and telangiectasias 3 years post-treatment, but with no influence on pain. K E Y W O R D Sbreast cancer, breast edema, fibrosis, intraoperative radiotherapy, pain, side effects, telangiectasias, whole breast radiotherapy

Radiodermatitis and Fibrosis in the Context of Breast Radiation Therapy: A Critical Review

“…Other radiation techniques have also been analysed, such as partial breast radiation [ 21 , 22 , 23 , 24 ] or intraoperative radiation therapy [ 25 , 26 , 27 , 28 ], which are designed to limit irradiation to the surgical site.…”