Analysis of c-kit expression in small cell lung cancer: Prevalence and prognostic implications

Camps, Carlos; Sirera, Rafael; Bremnes, Roy M.; Garde, J.; Safont, María José; Blasco, Ana; Berrocal, A.; Sánchez, José Javier; Calabuig, Consuelo; Martorell, Miguel

doi:10.1016/j.lungcan.2006.02.003

Cited by 27 publications

(26 citation statements)

References 35 publications

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“…In SCLC, c-Kit RNA and protein is found overexpressed in tumor cell lines and primary tumor tissues, and it is hypothesized that there is an SCF/c-Kit autocrine loop involved in this cancer. 12,38,41,42 Our data highly support the function of c-Kit in this cancer type given that CK6 antagonized signaling in SCLC tumor cell lines and blocked their growth in vitro and in vivo. We analyzed c-Kit expression in primary lung tumor samples by immunohistochemistry and found 46% of SCLC tumors were c-Kit positive, consistent with previous reports of 37 to 86% of SCLC tumors being positive for c-Kit.…”

Section: Discussionsupporting

confidence: 66%

A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

Lebron

Brennan

Damoci

et al. 2014

Cancer Biology & Therapy

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Section: Discussionsupporting

confidence: 66%

A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

Lebron

Brennan

Damoci

et al. 2014

Cancer Biology & Therapy

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“…The protein expression in SCLC varies among researchers [6][7][8][9][10][11][12][13][14][15]; the percentage ranges from 30 [15] to 80% [6]. It is reported that KIT expression without KIT gene mutations is due to KIT gene amplification [15].…”

Section: Discussionmentioning

confidence: 99%

“…In SCLC, it is known that SCLC frequently shows KIT protein [6][7][8][9][10][11][12][13][14][15]. In addition, one report showed that a few KIT gene mutations were present in SCLC [13], but others identified no mutations of KIT in SCLC [12,14,15].…”

Section: Introductionmentioning

confidence: 99%

Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Terada

2009

Med Oncol

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An extremely rare case of primary small cell carcinoma of the pleura with an emphasis on KIT and platelet-derived growth factor receptor-α (PDGFRA) genes is reported here. A 67-year-old man underwent left testicular orchiectomy because of a testicular tumor. The tumor was immunohistochemically shown to be diffuse large B-cell lymphoma. The patient was treated with chemotherapy and radiation and followed up in our hospital. Eight years after the orchiectomy, the patient (75 years old) developed left pleural tumor and pleural effusion, and a biopsy was performed. The biopsy revealed a medullary malignant tumor consisting of small round and spindle cells. The following three possibilities were considered: recurrent lymphoma, mesothelioma, and small cell carcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin, synaptophysin, CD56, KIT, and PDGFRA, but negative for CEA, cytokeratin 5/6, neuron-specific enolase, chromogranin, CD45, CD3, CD20, CD45RO, CD15, CD30, calretinin, WT-1, B72.3, D2-40, and TTF-1. Therefore, a diagnosis of pleural small cell carcinoma was made. A molecular genetic analysis using PCR-direct sequencing identified no mutations of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes. The patient was treated with chemotherapy (cisplatin) and radiation (50 Gray). The present case is the first reported case of primary small cell carcinoma of the pleura with an examination of KIT and PDGFRA expressions and KIT and PDGFRA gene mutations.

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“…Recent studies of SCLC revealed that KIT protein is expressed in a significant percentage of SCLC [9][10][11][12][13][14][15][16][17][18]. In addition, one report showed that KIT gene mutations were present in SCLC [16], but others did not [15,17,18].…”

Section: Introductionmentioning

confidence: 99%

Primary small cell carcinoma of the mediastinum: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Terada

2008

Med Oncol

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The author reports herein an extremely rare case of primary small cell carcinoma of the mediastinum with an emphasis on KIT and PDGFRA genes. A 66-year-old man was found to have a mediastinal tumor on a routine chest X-ray examination, and was admitted to our hospital. Imaging modalities revealed a 5 x 4 cm tumor in the middle mediastinum near the bronchial carina. No other tumors were detected in the body including the lungs. Video-assisted thoracoscopy confirmed the mediastinal tumor, and a large incisional biopsy was performed. The tumor was histologically small cell carcinoma. An immunohistochemical study revealed positive reactions for cytokeratins (AE1/3, polyclonal), synaptophysin, neuron-specific enolase, CD56, KIT, and PDGFRA, and negative reactions for chromogranin, CEA, CD45, CD20, and CD3. Ki-67 labeling showed a value of 80%. A molecular genetic analysis using PCR-direct sequencing identified no mutations of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes. The patient received radiation and chemotherapy, and the tumor was fully resolved. The patient has remained free of recurrence for 6 years after the first presentation. The present case is the first reported case of primary small cell carcinoma of the mediastinum with an examination of KIT and PDGFRA expressions and KIT and PDFGRA gene mutations.

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Analysis of c-kit expression in small cell lung cancer: Prevalence and prognostic implications

Cited by 27 publications

References 35 publications

A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Primary small cell carcinoma of the mediastinum: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

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