Analysis of case-cohort data: A comparison of different methods

Onland‐Moret, N. Charlotte; A, Daphne L. van der; Schouw, Yvonne T. van der; Buschers, Wim; Elias, Sjoerd G.; Gils, Carla H. van; Koerselman, Jeroen; Roest, Mark; Grobbee, Diederick E.; Peeters, Petra H.M.

doi:10.1016/j.jclinepi.2006.06.022

Cited by 106 publications

(103 citation statements)

References 8 publications

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“…At time of event, these case subjects had the same weight as the subcohort members and only then contributed to the risk sets. Results from a case-cohort study closely resemble analyses on a full cohort (29). All models were adjusted for sex, age, and cohort (model 1).…”

Section: Statistical Analysesmentioning

confidence: 78%

Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)

et al. 2014

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Experimental data suggest a role for advanced glycation end products (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, epidemiological evidence of an association between high plasma AGEs and increased cardiovascular risk remains inconclusive. Therefore, in a case-cohort study comprising 134 cardiovascular case subjects and a random subcohort of 218 individuals (including 65 cardiovascular case subjects), all with T2DM and nested in the European Prospective Investigation into Cancer and Nutrition in the Netherlands (EPIC-NL) study, plasma levels of protein-bound Nε-(carboxymethyl)lysine, Nε-(carboxyethyl)lysine, and pentosidine were measured with liquid chromatography. AGEs were loge-transformed, combined in a z-score, and the association with incident cardiovascular events was analyzed with Cox proportional hazard regression, adapted for case-cohort design (Prentice method). After multivariable adjustment (sex, age, cohort status, diabetes duration, total cholesterol to HDL-cholesterol ratio, smoking, systolic blood pressure, BMI, blood pressure–, cholesterol- and glucose-lowering treatment, prior cardiovascular events, and triglycerides), higher plasma AGE z-scores were associated with higher risk of incident cardiovascular events in individuals without prior cardiovascular events (hazard ratio 1.31 [95% CI: 1.06–1.61]). A similar trend was observed in individuals with prior cardiovascular events (1.37 [0.63–2.98]). In conclusion, high plasma AGEs were associated with incident cardiovascular events in individuals with T2DM. These results underline the potential importance of AGEs in development of CVD.

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Section: Statistical Analysesmentioning

confidence: 78%

Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)

et al. 2014

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“…Differences were examined using mean and SD for continuous variables, with p values from an ANOVA test or using number and per cent for categorical variables, with χ 2 test. Multivariable Prentice-weighted Cox-regression was used, allowing for the nested case-cohort design [21,22], to examine associations between total 25(OH)D (quartiles) and incident diabetes. ≥50 nmol/l) groups in a multivariable-adjusted model that included the covariates specified in model 5 above.…”

Section: Discussionmentioning

confidence: 99%

Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies

et al. 2012

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“…This approach provides association estimates that resemble those from full-cohort analysis, in particular when the sampling fraction is Ն10%. 13 Baseline characteristics of the subcohort were examined by ␣-Adducin genotype. Hardy-Weinberg equilibrium (HWE) was tested with the 2 exact test (the expected count under the HWE was less than 5 for 1 of the 3 genotypes among the controls).…”

Section: Discussionmentioning

confidence: 99%

α-Adducin Gly 460 Trp Variant Increases the Risk of Stroke in Hypertensive Dutch Women

et al. 2008

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Abstract-The Gly460Trp variant of the ␣-adducin gene has been associated with renal sodium retention and salt-sensitive hypertension. Independent of blood pressure, salt sensitivity has been related to cerebrovascular events. We studied the risk of stroke, coronary heart disease (CHD), and myocardial infarction (MI) associated with the ␣-adducin variant and examined the extent to which this risk is modified by the presence of hypertension. We performed a case-cohort study in a prospective cohort of 15 236 initially healthy Dutch women. We applied a Cox proportional hazards model with an estimation procedure adapted for case-cohort designs to study the relation of the polymorphism and CHD (nϭ210), MI (nϭ71), any stroke (nϭ74), and ischemic stroke (nϭ49). Subjects with the Gly460Trp variant had a 2.8 times higher risk of stroke (95% confidence intervals [CI] 1.3 to 5.8) under the dominant genetic model, which did not attenuate after adjustment. The same pattern was found under per-allele comparison. Risk of ischemic stroke in the variant allele carriers was 3.9 times higher than in subjects with the common genotype (95% CI 1.7 to 8.6) using dominant inheritance model. The same patterns were found under per-allele comparison. CHD and MI were not related to the variant. The risk of ischemic stroke was more pronounced among women with systolic hypertension (10.9; 95% CI 3.6 to 31.5). The findings in this prospective study in a population based cohort of Dutch women strongly suggest that presence of the ␣-adducin Gly460Trp polymorphism increases the risk of stroke. This risk is particularly elevated in the presence of systolic hypertension. (Hypertension. 2008;51:1665-1670.)

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Analysis of case-cohort data: A comparison of different methods

Cited by 106 publications

References 8 publications

Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)

Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)

Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies

α-Adducin Gly 460 Trp Variant Increases the Risk of Stroke in Hypertensive Dutch Women

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