Analysis of Clinical and Regional Distribution Characteristics of Obstructive Meibomian Gland Dysfunction in China: A Multicenter Study

Li, Yan; Lu, Jing; Zhou, Qizhi; Wang, Congxiang; Zeng, Qingyan; Chen, Tiehong; Liu, Chang; Kang, Yanwei; Li, Shaowei

doi:10.1080/02713683.2020.1752387

Cited by 7 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LLT, blinking pattern, and meibomian gland images were assessed using the LipiView II (TearScience, Morrisville, NC, USA) ocular surface interferometer. In recent years, thanks to the development of the ocular surface interferometer, an increased number of studies regarding the tear lipid layer in dry eye patients have been published [31][32][33]. It has been hypothesized that the alteration of the lipid layer of tears caused by chronic inflammation and the dysfunction of the meibomian glands may be linked to three factors: (1) peri-glandular fibrosis, inflammation of the lacrimal glands, including the meibomian glands, linked to systemic inflammatory disease; (2) reduced mobility of the eyelids due to fibrosis of the connective tissue, which causes incomplete blinking; and (3) increased osmolarity due to greater evaporation of tears from the ocular surface, which is a consequence of the thinning of the lipid layer [28,34,35].…”

Section: Discussionmentioning

confidence: 99%

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

et al. 2020

View full text Add to dashboard Cite

Background: In systemic sclerosis (SSc) patients, dry eye syndrome (DES) is the most frequent ocular feature. The aim of this study was to investigate ocular DES-related SSc patients and to establish any correlation with the severity of the disease. Methods: Retrospectively, data from 60 patients with SSc underwent ophthalmic examination, where non-invasive film tear break-up time (NIF-TBUT), tear film lipid layer thickness (LLT), anesthetic-free Schirmer test I, tear osmolarity measurement (TearLab System), and modified Rodnan skin score (mRSS) data were collected. The visual analog scale (VAS) and Symptom Assessment in Dry Eye (SANDE) methods were utilized. The results were correlated with mRSS and the duration of SSc. Results: Severe DES occurred in 84% of cases, and was more severe in women. The eyelids were involved in 86.6%, secondary to meibomian gland disease (MGD). A direct correlation was found between the tear osmolarity (mean 328.51 ± 23.8 SD) and skin score (mRSS) (r = 0.79; p < 0.01). Significantly reduced NIF-TBUT, LLT, and Schirmer test I values were observed in the case of severe skin involvement. Conclusions: SSc patients show lipid tear dysfunction related to the severity and duration of the disease due to inflammation and the subsequent atrophy of the meibomian glands.

show abstract

Section: Discussionmentioning

confidence: 99%

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…MGD was diagnosed based on the presence of ocular surface-related symptoms, lid margin abnormality score (irregular shape; vascular engorgement; bulge, ester cap, or plug in MG orifices), poor meibum quality, and a poor meibum expressibility score [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and Demodex Infestation

Lian

et al. 2022

JCM

View full text Add to dashboard Cite

The purpose of this study was to compare the differences between uneven meibomian gland (MG) atrophy with and without Demodex infestation based on the index of uneven atrophy score (UAS). In this retrospective cohort study, 158 subjects were recruited, including 66 subjects in the Demodex-positive MGD group, 49 subjects in the Demodex-negative MGD group, and 43 subjects as normal control. No significant difference was verified in OSDI, TMH, TBUT, CFS, lid margin score, and meibograde (all p > 0.05) between the Demodex-positive MGD group and the Demodex-negative MGD group. The UAS index of the upper eyelid or both eyelids was significantly higher in the Demodex-positive group in comparison with the normal control group and Demodex-negative group and the difference was statistically significant between the three groups. The UAS was significantly positive correlation with OSDI (r = 0.209, p < 0.05), lid margin score (r = 0.287, p < 0.001), and meibograde (r = 0.356, p < 0.001), which has a significant negative correlation with TBUT (r = −0.248, p < 0.05). Thus, Demodex infestation can cause uneven MG atrophy and we propose a novel index of UAS, which is used to evaluate uneven atrophy of MGs and as a morphological index of Demodex infestation.

show abstract

“…19,20 Yarıklı lamba mikroskopi ve meibografi yardımıyla kapak kenarı, meibomian bez yapısı ve fonksiyonu değerlendirmeleri yapıldı. 17,21 Kapak kenarı anormallik skoru (KKAS) şu şekilde belirlendi: 0=normal kapak kenarı; 1=kapak kenarında hafif hiperemi; 2=düzensiz ve kalınlaşmış kapak kenarı + meibomian bez ağız tıkanıklığı; 3=bariz neovaskülarizasyonun eşlik ettiği hipertrofik kapak kenarı + meibomian bez ağız tıkanıklığı. 21 Üst göz kapağının orta 1/3'üne dijital baskı uygulanarak, 5 adet meibomian bezin eksprese edilebilirliği incelendi.…”

Section: Gereç Ve Yöntemlerunclassified

“…17,21 Kapak kenarı anormallik skoru (KKAS) şu şekilde belirlendi: 0=normal kapak kenarı; 1=kapak kenarında hafif hiperemi; 2=düzensiz ve kalınlaşmış kapak kenarı + meibomian bez ağız tıkanıklığı; 3=bariz neovaskülarizasyonun eşlik ettiği hipertrofik kapak kenarı + meibomian bez ağız tıkanıklığı. 21 Üst göz kapağının orta 1/3'üne dijital baskı uygulanarak, 5 adet meibomian bezin eksprese edilebilirliği incelendi. Meibum eksprese edilebilirlik skoru (MEES) şu şekilde hesaplandı: 0=meibomian bezlerin hepsi eksprese edilebilir; 1=3 veya 4 meibomian bez eksprese edilebilir; 2=1 veya 2 meibomian bez eksprese edilebilir; 3=meibomian bezlerin hiçbiri eksprese edilemez.…”

Section: Gereç Ve Yöntemlerunclassified

“…Meibum eksprese edilebilirlik skoru (MEES) şu şekilde hesaplandı: 0=meibomian bezlerin hepsi eksprese edilebilir; 1=3 veya 4 meibomian bez eksprese edilebilir; 2=1 veya 2 meibomian bez eksprese edilebilir; 3=meibomian bezlerin hiçbiri eksprese edilemez. 17,21 Meibum kalite skoru (MKS) şu şekilde belirlendi: 0=normal berrak meibum; 1=normal viskoziteye sahip opak meibum; 2=artmış viskoziteye sahip opak meibum; 3=diş macunu kıvamında meibum. 21 Ön segment modül eklentili OKT cihazı yardımıyla noninvaziv olarak üst ve alt göz kapaklarındaki meibomian bez yapılarının kızılötesi görüntüsü (meibografi) elde edildi.…”

Section: Gereç Ve Yöntemlerunclassified

See 1 more Smart Citation

Effects of Cataract Surgery on Ocular Surface Parameters and Dry Eye Development: Prospective Clinical Study

ÇANKAYA PALAS,

ÖZTÜRK,

ÖZEN

2024

Turkiye Klinikleri J Ophthalmol

View full text Add to dashboard Cite

Bu çalışmada, fakoemülsifikasyon cerrahisinin, kuru göz gelişiminde rolü olabilecek çoklu oküler yüzey parametrelerine etkilerini kapsamlı bir şekilde incelemeyi amaçladık. Gereç ve Yöntemler: Cerrahi öncesi kuru gözü olmayan 40 katarakt olgusunun 40 gözü çalışmaya dâhil edildi. Oküler Yüzey Hastalık İndeksi [Ocular Surface Disease Index (OSDİ)] skoru, korneal-konjonktival boyanma dereceleri, Schirmer testi, prekorneal gözyaşı filmi kalınlığı (PrGFK), gözyaşı menisküs yüksekliği (GMY), gözyaşı menisküs derinliği (GMD), gözyaşı kırılma zamanı (GKZ), kapak kenarı anormallik skoru (KKAS), meibum eksprese edilebilirlik skoru (MEES), meibum kalite skoru (MKS) ve meiboskor değerleri; cerrahi öncesi (başlangıçta) ve cerrahi sonrası 1. haftada, 1 ve 3. ayda karşılaştırıldı. OSDİ skoru ≥13, GKZ <10 sn ve Schirmer değeri <10 mm olan olgular kuru göz hastası olarak kabul edildi. Bulgular: Başlangıca kıyasla 1. haftada, 1 ve 3. ayda, OSDİ skorunda (p<0,001) ve korneal-konjonktival boyanma derecelerinde (p<0,05) anlamlı artışlar varken, Schirmer (p<0,001), PrGFK (p<0,001), GMY (p<0,01), GMD (p<0,01) ve GKZ (p<0,001) değerlerinde anlamlı azalışlar vardı. Ancak cerrahi öncesi ve sonrası KKAS, MEES, MKS ve meiboskor değerleri benzerdi (p>0,05). Başlangıca kıyasla cerrahi sonrası 1. haftada, 1 ve 3. ayda kuru göz hastalığı olan olguların sayısı anlamlı arttı (p<0,01). Sonuç: Çalışmamızda fakoemülsifikasyon sonrası OSDİ skoru, korneal-konjonktival boyanma dereceleri, Schirmer testi, PrGFK, GMY, GMD ve GKZ değerleri gibi oküler yüzey parametrelerinin kötüleştiğini, KKAS, MEES, MKS ve meiboskor değerlerinin ise değişmediğini belirledik. Ek olarak cerrahi sonrası kuru gözün erken dönemde geliştiğini ve 3. ayda hâlâ tam düzelmediğini saptadık. Anah tarKe li me ler: Gözyaşı menisküs derinliği; gözyaşı menisküs yüksekliği; katarakt cerrahisi; kuru göz; meiboskor ABS TRACT Objective: We aimed to investigate comprehensively effects of phacoemulsification surgery on multiple ocular surface parameters that might play a role in dry eye development. Material and Methods: Forty eyes of 40 cataract cases without preoperative dry eye were included in study. Ocular Surface Disease Index (OSDI) score, corneal-conjunctival staining grades, Schirmer test, precorneal tear-film thickness (PrTFT), tear-meniscus height (TMH), tear-meniscus depth (TMD), tear break-up time (TBUT), lid margin abnormality score (LMAS), meibum expressibility score (MES), meibum quality score (MQS), and meiboscore values were compared before surgery (at baseline) and at 1 st week, 1 st and 3 rd month after surgery. Cases with OSDI score ≥13, TBUT<10 seconds and Schirmer value <10 millimeters were accepted as dry eye patient. Results: At 1 st week, 1 st and 3 rd month compared to baseline, there were significant increases in OSDI score (p<0.001) and corneal-conjunctival staining grades (p<0.05), while there were significant decreases in Schirmer (p<0.001), PrTFT (p<0.001), TMH (p<0.01), TMD (p<0.01) and TBUT (p<0.001) values. However, LMAS, MES, MQS and meiboscore values were ...

show abstract

Analysis of Clinical and Regional Distribution Characteristics of Obstructive Meibomian Gland Dysfunction in China: A Multicenter Study

Cited by 7 publications

References 42 publications

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity

Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and Demodex Infestation

Effects of Cataract Surgery on Ocular Surface Parameters and Dry Eye Development: Prospective Clinical Study

Contact Info

Product

Resources

About