Analysis of clinical trials on biomaterial and therapeutic applications of chitosan: A review

Kantak, Maithili; Bharate, Sonali S.

doi:10.1016/j.carbpol.2021.118999

Cited by 73 publications

(33 citation statements)

References 120 publications

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“…Liposomes are known to be biocompatible; additionally, numerous studies show that liposomal entrapment can reduce the toxicity of incorporated compounds [49,50]. The low toxicity of chitosan is also well established [51]. Hence, the delivery system comprising the natural ingredients RES, liposomes, and chitosan hydrogel, all considered non-toxic, should be safe.…”

Section: Res Formulationmentioning

confidence: 99%

Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginalTM Tissue Model

et al. 2022

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The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered non-toxic and safe on their own, the compatibility of the final formulation must be evaluated for its biocompatibility and non-irritancy to the vaginal mucosa. As a preclinical safety assessment, the impact of RES formulation on the tissue viability, the effect on barrier function and cell monolayer integrity, and cytotoxicity were evaluated using the cell-based vaginal tissue model, the EpiVaginal™ tissue. RES liposomes-in-hydrogel formulations neither affected the mitochondrial activity, nor the integrity of the cell monolayer in RES concentration up to 60 µg/mL. Moreover, the barrier function was maintained to a greater extent by RES in formulation, emphasizing the benefits of the delivery system. Additionally, none of the tested formulations expressed an increase in lactate dehydrogenase activity compared to the non-treated tissues. The evaluation of the RES delivery system suggests that it is non-irritant and biocompatible with vaginal tissue in vitro in the RES concentrations considered as therapeutic.

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Section: Res Formulationmentioning

confidence: 99%

Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginalTM Tissue Model

et al. 2022

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“…To bridge this gap, novel modifications of chitosan to enhance its broader resistance, or non-destructive chemical cross-linking between polyphenols and chitosan, might be the solution, which, however, appears to be a new challenge. Fortunately, there have already been some clinical trials on polyphenols 241 and chitosan carriers, 242 and clinical studies on OCDSs for gene delivery are also involved, which would guide us in the right direction.…”

Section: Discussionmentioning

confidence: 99%

Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

2022

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“…Besides, chitosan (CS) is a natural polymer that has the bacteriostatic property, chelation, biocompatibility, biodegradability, and avirulent feature. CS has received widespread acceptance in many biomedical applications, such as wound dressings, biologic scaffolds, drug delivery, and metal ion adsorption [56][57][58][59][60][61][62]. Nonetheless, chitosan is insoluble and usually combined with an acid solvent, which in turn leaves the resulting products with acid residue that hampers cell growth [56,58,[63][64][65][66].…”

Section: Introductionmentioning

confidence: 99%

“…CS has received widespread acceptance in many biomedical applications, such as wound dressings, biologic scaffolds, drug delivery, and metal ion adsorption [56][57][58][59][60][61][62]. Nonetheless, chitosan is insoluble and usually combined with an acid solvent, which in turn leaves the resulting products with acid residue that hampers cell growth [56,58,[63][64][65][66]. The presence of water-soluble chitosan can address the problem, because organisms can absorb chitosan efficiently.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Needleless Electrospinning Polyvinyl Alcohol/Water-Soluble Chitosan Nanofibrous Membranes: Antibacterial Property and Filter Efficiency

et al. 2022

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Electrospinning is an efficient method of producing nanofibers out of polymers that shows a great potential for the filtration territory. Featuring water-soluble chitosan (WS-CS), a low-pollution process and a self-made needleless machine, PVA/WS-CS nanofibrous membranes were prepared and evaluated for nanofiber diameter, bacteriostatic property, filtration efficiency, pressure drop, and quality factor. Test results indicate that the minimal fiber diameter was 216.58 ± 58.15 nm. Regardless of the WS-CS concentration, all of the PVA/WS-CS nanofibrous membranes attained a high porosity and a high water vapor transmission rate (WVTR), with a pore size of 12.06–22.48 nm. Moreover, the membranes also exhibit bacteriostatic efficacy against Staphylococcus aureus, an optimal quality factor of 0.0825 Pa−1, and a filtration efficiency as high as 97.0%, that is 72.5% higher than that of common masks.

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Analysis of clinical trials on biomaterial and therapeutic applications of chitosan: A review

Cited by 73 publications

References 120 publications

Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginalTM Tissue Model

Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginalTM Tissue Model

Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

Preparation of Needleless Electrospinning Polyvinyl Alcohol/Water-Soluble Chitosan Nanofibrous Membranes: Antibacterial Property and Filter Efficiency

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