In the present era of Industry 4.0, organizations are transforming from traditional production systems to digital production systems. This transformation is in terms of additional deployment of technologies that lead to digitization and integration of products and services, business processes and customers, etc. A high volume of unstructured data is being created across different processes due to digitization. The digitization captures the data that includes text, images, multimedia, etc., due to multiplicity of platforms, e.g., machine-to-machine communications, sensors networks, cyber-physical systems, and Internet of Things. Managing this huge data generated from different sources has become a challenging task. Big data analytics (BDA) may be helpful in managing this unstructured data for effective decision making and sustainable operations. Many organizations are struggling to integrate BDA with their manufacturing processes for sustainable operations. The application of BDA from a sustainability perspective is not extensively researched in the current literature. Therefore, firstly this study explores the contribution of BDA in sustainable manufacturing operations. It further identifies strategic factors for the successful application of BDA in manufacturing for sustainable operations. For a detailed analysis of strategic factors in manufacturing, a hybrid approach comprising the analytic hierarchy process, fuzzy TOPSIS and DEMATEL is used. Results revealed that development of contract agreement among all stakeholders, engagement of top management, capability to handle big data, availability of quality and reliable data, developing team of knowledgeable, and capable decision-makers have emerged as major strategic factors for the application of BDA in the manufacturing sector for sustainable operations. Major contribution of this study is in analyzing BDA benefits for manufacturing sector, identifying major strategic factors in implementation and categorization of these factors into cause and effect group. These findings may be used by managers as guidelines for successful implementation of BDA across different functions in their respective organization to achieve sustainable operations goal. The results of this study will also motivate industry professionals to integrate BDA with their manufacturing functions for effective decision making and sustainable operations.