Analysis of Common Polymorphisms in Angiotensin-converting Enzyme and Apolipoprotein E Genes and Human Longevity in Colombia

Forero, Diego A.; Pinzón, Jorge Eduardo Caminos; Arboleda, Gonzálo; Londoño, Juan José Yunis; Álvarez, Claudia; Cataño, Nohra; Arboleda, Humberto

doi:10.1016/j.arcmed.2006.04.001

Cited by 22 publications

(24 citation statements)

References 39 publications

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“…No ε4 allele was found. When evaluating the frequencies of the APOE genotypes in the group of patients and in the group of control subjects, the distribution was comparable to that found in the analysis of the total population (38,39).…”

Section: Resultssupporting

confidence: 72%

“…In a study conducted in 2006 in Bogotá involving residents between 18 and 106 years of age, 75% of the population were found with the APOE3/3 genotype, 15% were of the APOE3/4 genotype, 8.2% were APOE2/3, 1.4% were of the APOE2/4 genotype, and 0.7% of the population were APOE2/2 or APOE4/4 (38). Similar results were found by another study conducted in 2007 involving 1,567 individuals from the Central and East parts of the country (39).…”

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confidence: 99%

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Diabetes mellitus en pacientes con enfermedad de Alzheimer: descripción clínica y correlación con el genotipo APOE en una muestra de población del departamento de Antioquia, Colombia

et al. 2012

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Section: Resultssupporting

confidence: 72%

mentioning

confidence: 99%

Diabetes mellitus en pacientes con enfermedad de Alzheimer: descripción clínica y correlación con el genotipo APOE en una muestra de población del departamento de Antioquia, Colombia

et al. 2012

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“…The sense primer was 5'-CTG GAG ACC ACT CCC ATC CTT TCT-3', and the antisense primer was 5'-GAT GTG GCC ATC ACA TTC GTC AGA T-3'. 14 The thermal cycling conditions were as follows: initial denaturising at 95 To avoid false-positive results of the ACE DD homozygote, 15 additional primers (one primer targeting a sequence in the Alu region) were used for amplifying the DD homozygote (5'-TGG GAC CAC AGC GCC CGC CAC TAC-3' and 5'-TCG CCA GCC CTC CCA TGC CCA TAA T-3').…”

Section: Dna Analysismentioning

confidence: 99%

Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population

Yang

Gong

Xie

et al. 2009

J Renin Angiotensin Aldosterone Syst

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Introduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population. Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population. Materials and methods. We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years. Results. No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group. When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884). Conclusions.No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population. IntroductionLongevity has always been a desire of humankind. Although human lifespan is influenced mostly by non-genetic factors, genetic factors also have an important impact on lifespan. [1][2][3] Angiotensin-converting enzyme (ACE) cleaves angiotensin I to yield the octapeptide angiotensin II, which is a potent vasoconstrictor. 4 An Alu insertion/deletion (I/D) in intron 16 of the ACE gene has been suggested to be involved in cardiovascular disease.5 Subjects bearing the D allele have higher circulating and tissue ACE levels than those with the I allele, and homozygosity of the ACE D allele has been linked to an increased risk for myocardial infarction, left ventricular hypertrophy and in-stent restenosis after angioplasty. 6A potential role of the ACE gene I/D polymorphism in longevity was proposed in a casecontrol study in French centenarians in 1994. In an Italian population and a Korean population, studies in centenarians have also shown no association of the ACE gene I/D polymorphism with longevity. 9,10 Another study in an Italian sample reported a role of gender in the association of the ACE gene I/D polymorphism with longevity.11 In China, data from an Uighur longevity group supported the association between the ACE gene I/D polymorphism and longevity. 12,13 Han is the most populous ethnic group in China. However, little information on ACE I/D genotypes has been obtained in Han Chinese longevity populations. In this study, we examined the distribution of ACE I/D genotype and allele frequencies in two groups: a longevity group aged over 90 years and a control group aged less than 60 years living in the Dujiang Weirs area, in Southwest China, and the association of the ACE gene I/D polymorphism with longevity was evaluated. Materials and methods Study samplesWe included 701 subjects in this study. The longevity group included 399 nonagenarians an...

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“…However, the association between the D allele and increased longevity has not been replicated in other studies on centenarians from Denmark, 11 France, 12 Italy, 13,14 Korea 15 or China (Han population). 16 To further complicate the issue, Forero et al 17 recently reported an age-related decrease of the D allele in a Latin-American population (Colombia). Controversy between studies can arise from different factors, including homogeneity of cohorts within a given report or geographic differences between studies.…”

Section: Introductionmentioning

confidence: 99%

Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort

Fiuza‐Luces

Ruiz

Rodríguez-Romo

et al. 2011

J Renin Angiotensin Aldosterone Syst

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The 287 bp Ins(I)/Del(D) polymorphism [rs1799752] in intron 16 of the angiotensin-converting enzyme (ACE) gene has been associated with extreme longevity (≥ 100 years) in some Caucasian and Asian cohorts, but this finding was not corroborated in other reports. We compared the allelic/genotypic frequency of the ACE I/D polymorphism among centenarians (N = 64, 100-108 years, 89.1% female) and nonagenarians (N = 47, 90-97 years, 76.6% female), and a control group of healthy young adults (n = 434, age 20-40 years, 50% female). All participants were of the same Caucasian (Spanish) descent. The ACE I/D genotype met Hardy-Weinberg expectations in all the cohorts. Allelic and genotypic frequencies did not differ by sex in any of the study groups (all p > 0.2). There were no differences in allelic or genotypic frequencies between groups, for example the frequency of the D allele was 62.3% in controls vs. 65.3% in the elderly (64.8% in centenarians). In summary, the ACE I/D polymorphism is not significantly associated with extreme longevity in the Spanish population. Further research is, however, necessary using other approaches. It also remains to be determined if the interaction of ACE genotypes with some other genetic variants exerts a potential effect on longevity.

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Analysis of Common Polymorphisms in Angiotensin-converting Enzyme and Apolipoprotein E Genes and Human Longevity in Colombia

Cited by 22 publications

References 39 publications

Diabetes mellitus en pacientes con enfermedad de Alzheimer: descripción clínica y correlación con el genotipo APOE en una muestra de población del departamento de Antioquia, Colombia

Diabetes mellitus en pacientes con enfermedad de Alzheimer: descripción clínica y correlación con el genotipo APOE en una muestra de población del departamento de Antioquia, Colombia

Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population

Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort

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