Analysis of Conjunctival Vascular Density in Scleral Contact Lens Wearers Using Optical Coherence Tomography Angiography

Jesus, Jeniffer; Dias, Libânia; Almeida, Inês; Costa, Tatiana P. Soares da; Chibante-Pedro, João

doi:10.1016/j.clae.2020.12.066

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…Some studies measured the nasal, temporal, superior, and inferior quadrants of the conjunctiva and found some differences in conjunctival vessel density among 4 quadrants [20,21], however, to ensure the comparability, the temporal side was selected uniformly for both the control group and CAD patients in this study. According to the layer segmentation criteria published in the prior research, we segmented the AS-OCTA images to acquire the conjunctival vessel images, which ranged from the conjunctival epithelium to a depth of 200 µm [12,20,22]. The conjunctival vessel density in control group was 30.10 ± 3.22% in this study, which was consistent with that reported in previous studies [20,21,23].…”

Section: Discussionsupporting

confidence: 88%

Assessment of conjunctival microvessels for patients with coronary artery disease using Optical Coherence Tomographic Angiography

Liu,

Sun,

Zhang

et al. 2023

Preprint

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Background To quantify conjunctival microvascular characteristics obtained by optical coherence tomographic angiography (OCTA) and investigate their relationship with the presence and severity of coronary artery disease (CAD). Methods This cross-sectional study included 103 consecutive CAD patients confirmed by coronary angiography and 125 non-CAD controls. The temporal conjunctivas along the limbus of each participant were scanned using OCTA. Quantification of conjunctival microvasculature was performed by AngioTool software. The severity of the disease was evaluated using SYNTAX and Gensini scores. Results Compared to the controls, the CAD group exhibited significantly lower vessel area density (30.22 ± 3.34 vs. 26.70 ± 4.43%, p < 0.001), lower vessel length density (6.39 ± 0.77 vs. 5.71 ± 0.89/m, p < 0.001), lower junction density (3.44 ± 0.56 vs. 3.05 ± 0.63/m, p < 0.001), and higher lacunarity (0.11 ± 0.03 vs. 0.14 ± 0.05, p < 0.001). Among all participants, lower vessel area density, lower vessel length density, lower junction density, and higher lacunarity were associated with greater odds of having CAD; the adjusted ORs (95% confidence intervals) per one SD decrease were 2.71 (1.71, 4.29), 2.51(1.61, 3.90), 2.06 (1.39, 3.05), and 0.36 (0.23, 0.58), respectively. Among CAD patients, junction density was negatively associated with the Gensini score (r=-0.359, p = 0.037) and the Syntax score (r=-0.350, p = 0.042) in women but not in men (p > 0.05). Conclusions Conjunctival microvascular characteristics were significantly associated with the presence of CAD. Junction density significantly associated with the severity of CAD among women patients.

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Section: Discussionsupporting

confidence: 88%

Assessment of conjunctival microvessels for patients with coronary artery disease using Optical Coherence Tomographic Angiography

Liu,

Sun,

Zhang

et al. 2023

Preprint

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“…In the remaining connective tissue, the blood vessels have a regular diameter and morphology, very similar to normal conjunctive; their cavities are visible, sometimes dilated, and filled with blood ( 47 ). A study of scleral contact lens (ScCL) wearers demonstrates that repeated use of ScCL can cause vascular alterations in conjunctiva detected by AS-OCTA ( 48 ). Recent research shows that AS-OCTA works best on superficial and non-pigmented conjunctiva lesions, and malignant lesions always accompanied by deeper and larger perilesional vessels, which could be a significant marker of clinical diagnosis ( 49 , 50 ).…”

Section: As-octa Precise Diagnosismentioning

confidence: 99%

Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography

Luo

Zhuo

2021

Front. Med.

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Optical coherence tomography angiography (OCTA) is the most relevant evolution based on optical coherence tomography (OCT). OCTA can present ocular vasculature, show detailed morphology for assessment, and quantify vessel parameters without intravenous dye agent. Research on the anterior segment OCTA (AS-OCTA) is only in its initial phase, and its advances in clinical diagnosis and treatment efficacy evaluations require a detailed comparison to traditional imaging methods. In this review of AS-OCTA, we summarize its technical features, imaging advances, current clinical applications in various eye diseases, as well as its limitations and potential future directions. AS-OCTA offers potential advantages in ophthalmic imaging, and with further development it could become a common tool in the near future.

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“…1 Since then, much has changed in SL research and the SL industry. Considerable research has been published about a variety of SL-related topics, such as the effects of SL wear on corneal 2,3 and conjunctival 4–6 tissues and on intraocular pressure (IOP). 7–9 Additional survey findings suggested that the rate of SL fitting increased from 2015 through 2019.…”

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confidence: 99%

Current Trends in Scleral Lens Prescription, Management, and Evaluation

Schornack

Nau²,

Harthan³

et al. 2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives: To report current trends in scleral contact lens prescription and management, including lens designs prescribed, care products recommended, and procedures performed during routine scleral lens (SL) evaluation. Methods: An online survey was designed by the Scleral Lenses in Current Ophthalmic Practice Evaluation study team and administered to eye care practitioners attending a specialty contact lens meeting. The survey was available from November 8, 2019, through March 31, 2020. Participants' demographic data were collected, along with information on lens diameters, landing zone (LZ) designs, recommended care products, and components of routine SL evaluation. Results: In total, 715 participants responded to at least one of the survey items of interest. Most lenses prescribed (63%) were 16 mm or more in diameter. Lenses with toric LZs were the most frequently prescribed (48%), followed by spherical (40%), quadrant-specific (8%), and impression-based or image-based designs (3%). Most participants (61%) recommended hydrogen peroxide products for lens care. Nonpreserved saline in a single-use vial was most frequently recommended to fill the bowl of the lens before application. Intraocular pressure was measured during SL evaluation by 45% of participants; 38% of participants routinely measured corneal thickness.Conclusions: Practitioners increasingly are prescribing SLs with advanced LZ designs. Most practitioners recommend hydrogen peroxide-based disinfection systems and single-use vials of nonpreserved saline for lens care and application. Because differences in components of routine SL evaluations were reported, clinicians may benefit from reaching a consensus on essential components of SL evaluation.

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Analysis of Conjunctival Vascular Density in Scleral Contact Lens Wearers Using Optical Coherence Tomography Angiography

Cited by 10 publications

References 19 publications

Assessment of conjunctival microvessels for patients with coronary artery disease using Optical Coherence Tomographic Angiography

Assessment of conjunctival microvessels for patients with coronary artery disease using Optical Coherence Tomographic Angiography

Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography

Current Trends in Scleral Lens Prescription, Management, and Evaluation

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