Analysis of contrast-enhanced MR images to assess renal function

Michoux, Nicolas; Vallée, Jean‐Paul; Péchère-Bertschi, Antoinette; Montet, Xavier; Buehler, Leo Hans; Beers, Bernard E. Van

doi:10.1007/s10334-006-0045-z

Cited by 46 publications

(19 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The motion artefacts are caused by respiratory motion, intestinal peristalsis, cardiac pulsations, or patient movement during data collection [32], [48]. In this way, GFR estimates can become strongly biased or even invalidated [55].…”

Section: ) Registrationmentioning

confidence: 99%

Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys

Hodneland

Hanson

Lundervold

et al. 2014

IEEE Trans. on Image Process.

View full text Add to dashboard Cite

Abstract-Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the kidneys requires proper motion correction and segmentation to enable an estimation of glomerular filtration rate through pharmacokinetic modeling. Traditionally, co-registration, segmentation, and pharmacokinetic modeling have been applied sequentially as separate processing steps. In this paper, a combined 4D model for simultaneous registration and segmentation of the whole kidney is presented. To demonstrate the model in numerical experiments, we used normalized gradients as data term in the registration and a Mahalanobis distance from the time courses of the segmented regions to a training set for supervised segmentation. By applying this framework to an input consisting of 4D image time series, we conduct simultaneous motion correction and two-region segmentation into kidney and background. The potential of the new approach is demonstrated on real DCE-MRI data from ten healthy volunteers.

show abstract

Section: ) Registrationmentioning

confidence: 99%

Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys

Hodneland

Hanson

Lundervold

et al. 2014

IEEE Trans. on Image Process.

View full text Add to dashboard Cite

show abstract

“…However, the field suffers from a lack of uniformity in data acquisition and analysis (5,6). One potential factor influencing the parameters derived from MR renography forms the type of administered contrast agent and the influence of dose and injection rate.…”

Section: Magneticmentioning

confidence: 99%

Comparison of Gd‐DTPA and Gd‐BOPTA for studying renal perfusion and filtration

Notohamiprodjo

Pedersen

Gläser

et al. 2011

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To measure the systematic error in perfusion and filtration parameters derived from magnetic resonance (MR) renography caused by protein binding of MR contrast agents. Materials and Methods:Eight healthy Danish Landrace pigs were examined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). In four pigs a bolus of gadopentetate-dimeglumine (Gd-DTPA; no protein binding) was injected, followed by gadobenate-dimeglumine (Gd-BOPTA; 10% protein binding). The order was reversed in the other four pigs. A two-compartment filtration model was generalized to allow for protein binding and fitted to whole-cortex region of interest (ROI) curves. Single-kidney plasma flow and volume, tubular flow (or GFR), and tubular transit time of both agents were compared. Results:The data show a strong systematic underestimation (P < 0.001) in GFR by Gd-BOPTA (33 6 7.2%), and no significant differences (P > 0.05) in plasma flow (2.2 6 18%), plasma volume (À1.7 6 7.8%) and tubular transit time (3.1 6 7.2%). The order of injection had no significant effect. Conclusion:Theory and experiments agree that perfusion parameters of both agents are comparable, whereas GFR is underestimated with Gd-BOPTA due to the dependence of relaxivity on protein content. Hence, GFR cannot be measured with protein-bound contrast agents, but the proposed dual-agent protocol may produce new functional indices measuring protein filtration.

show abstract

“…7) (62,(64)(65)(66)(67)(68)(69)(70)(71)(72). To data there are only a few clinical studies measuring renal perfusion.…”

Section: Functional Mr Imaging Of the Kidneysmentioning

confidence: 99%

Renovascular imaging in the NSF Era

Roditi

Maki

Oliveira

et al. 2009

Magnetic Resonance Imaging

View full text Add to dashboard Cite

The detection of the association between nephrogenic systemic fibrosis (NSF), a rare but potentially life‐threatening disease only encountered in patients with severely impaired renal function, and the previous administration of some Gd‐chelates has cast a shadow on the administration of Gd‐chelates in patients with chronic renal failure. So far, contrast‐enhanced MR‐angiography (MRA) was considered the best diagnostic modality in patients with suspected renal disease. This review explores the most appropriate use of renal MRA with a focus on newly developed nonenhanced MRA techniques. Nonenhanced MRA techniques mainly based on SSFP with ECG‐gating allow for acceptable spatial resolution to visualize at least the proximal parts of the renal arteries. In addition functional renal imaging techniques and their current clinical role are critically appreciated. J. Magn. Reson. Imaging 2009;30:1323–1334. © 2009 Wiley‐Liss, Inc.

show abstract

Analysis of contrast-enhanced MR images to assess renal function

Cited by 46 publications

References 87 publications

Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys

Segmentation-Driven Image Registration-Application to 4D DCE-MRI Recordings of the Moving Kidneys

Comparison of Gd‐DTPA and Gd‐BOPTA for studying renal perfusion and filtration

Renovascular imaging in the NSF Era

Contact Info

Product

Resources

About