The results of the analysis indicate that, during Instrument Meteorological Conditions (IMC), the RNP approach to 13C uses an average of 14% less fuel than the ILS approach on to 13C. For narrow body aircrafts, this is equivalent to on an average a savings of $47 per flight per approach (at $3 a gallon). During Visual Meteorological Conditions (VMC) the least average fuel burn arrival flow for VFR approach procedures is to runways 4R or 31C (174.9 kg) followed by 13C (+11%), and 22L (+19%). During Instrument Meteorological Conditions (IMC) the least average fuel burn arrival flow for ILS approach procedures is to runway 31C (207.06 kg) followed by, 4R (+6.5%) and 13C (+33%). To ensure equity in fuel burn between flights arriving from the east and the west during VMC, 13C is the most equitable runway with the 14% difference in fuel burn between east and west flows, followed by 4R (18% difference), 22L (96% difference) and 31C (148% difference). During IMC, 13C (56%) is the most equitable runway followed by 4R (72%) and 31C (211%).For narrow body aircrafts at MDW, the fuel burn rate in level flight (35 kg/min) is 108% greater than the fuel burn for near-idle descent segments (15 kg/min) and 25% greater than fuel burn on the final approach segment (25 kg/min). These results quantify the benefits of the RNP approach onto 13C and identify an opportunity for a decision-support tool to select runway configuration based on wind magnitude/direction, as well as fuel burn.