Analysis of determinant factors of liver fibrosis progression in ex-thalassemic patients

Rostami, Tahereh; Monzavi, Seyed Mostafa; Khoshdel, Alireza; Behfar, Maryam; Hamidieh, Amir Ali

doi:10.1007/s12185-020-02998-4

Cited by 2 publications

(3 citation statements)

References 58 publications

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“…42 When post-HSCT iron depletion is regular and efficient, hepatic fibrosis and even cirrhosis can be reversed. 41 This highlights the need for both longterm monitoring of hepatic and iron status and adequate 43 and is a preferred method in this setting. Alternatively, deferasirox is a relatively safe and effective treatment with higher rates of patient satisfaction compared to phlebotomy.…”

Section: Hematopoietic Stem Cell Transplant Patientsmentioning

confidence: 99%

“…40 Furthermore, bone marrow and liver iron released from the toxicity of pre-transplantation conditioning regimen may potentiate this condition. 41 High iron loading with hepatic iron contents over 16 mg/g dry weight is associated with fibrosis progression following transplantation. 42 When post-HSCT iron depletion is regular and efficient, hepatic fibrosis and even cirrhosis can be reversed.…”

Section: Etiologies Of Secondary Iron Overload and Their Pathophysiol...mentioning

confidence: 99%

“… 42 When post-HSCT iron depletion is regular and efficient, hepatic fibrosis and even cirrhosis can be reversed. 41 This highlights the need for both long-term monitoring of hepatic and iron status and adequate iron depletion treatment. Phlebotomy until complete removal of excess iron is an effective treatment 43 and is a preferred method in this setting.…”

Section: Etiologies Of Secondary Iron Overload and Their Pathophysiol...mentioning

confidence: 99%

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Secondary Iron Overload and the Liver: A Comprehensive Review

Pinyopornpanish¹,

Tantiworawit²,

Leerapun³

et al. 2023

J Clin Transl Hepatol

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Iron overload is a condition involving excessive iron deposit in various organs, the liver being the main target organ for iron deposition and overload which are associated with significant liver morbidity and mortality. Iron overload can be categorized into primary and secondary causes. Primary iron overload, so-called hereditary hemochromatosis, is a wellrecognized disease with available standard treatment recommendations. However, secondary iron overload is a more diverse disease with many unclear areas to be explored. Secondary iron overload is more prevalent than primary iron overload and occurs as a consequence of various causes which differ significantly across geographic regions. The main causes of secondary iron overload are iron-loading anemias, and chronic liver disease. The liver-related outcomes, patient outcomes, and treatment recommendations in these patients differ depending on the cause of iron overload. This review summarizes the causes, pathophysiology, liver-related outcomes, disease outcomes, and treatments of secondary iron overload.

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Section: Hematopoietic Stem Cell Transplant Patientsmentioning

confidence: 99%

Section: Etiologies Of Secondary Iron Overload and Their Pathophysiol...mentioning

confidence: 99%

Section: Etiologies Of Secondary Iron Overload and Their Pathophysiol...mentioning

confidence: 99%

See 1 more Smart Citation

Secondary Iron Overload and the Liver: A Comprehensive Review

Pinyopornpanish¹,

Tantiworawit²,

Leerapun³

et al. 2023

J Clin Transl Hepatol

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Evaluation of hepatic fibrosis by transient elastography in βthalassemia children before and after hematopoietic stem cell transplantation

Salama,

Elhawary,

Ziada

et al. 2023

EGJH

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Background Iron overload is a major concern in all patients with transfusion-dependent thalassemia (TDT). The liver, being a target for iron deposition is at risk of developing liver fibrosis or even cirrhosis. Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment in clinical practice, a process that is surrounded by several precautions and complications that may affect the liver condition as well. Aim To evaluate the degree of hepatic fibrosis in children with TDT before and after HSCT. Methodology Twenty-five children with TDT who underwent HSCT were investigated by serum ferritin in addition to the assessment of liver fibrosis using transient elastography by FibroScan and liver fibrosis scores before and 1-year after HSCT. Results Out of the 25 children enrolled, only 16 completed a 1-year post-transplantation follow-up period. Slightly increased liver stiffness values measured by FibroScan 1-year post-transplantation, but the patients were still having the same degree of fibrosis of the pre-transplant period. FIB-4 score and APRI also showed statistically significant increase post-transplant as compared to pre-transplantation. Conclusion Stationary degree of fibrosis in thalassaemic children after HSCT with slight increases in the liver stiffness values by transient elastography that necessitates longer follow-up of the fibrosis status of patients’ post-transplant. Transient elastography is considered a helpful noninvasive tool for assessment of the hepatic status before and after HSCT.

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Analysis of determinant factors of liver fibrosis progression in ex-thalassemic patients

Cited by 2 publications

References 58 publications

Secondary Iron Overload and the Liver: A Comprehensive Review

Secondary Iron Overload and the Liver: A Comprehensive Review

Evaluation of hepatic fibrosis by transient elastography in βthalassemia children before and after hematopoietic stem cell transplantation

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