Analysis of Different European Hazelnut (<i>Corylus avellana</i> L.) Cultivars: Authentication, Phenotypic Features, and Phenolic Profiles

Ciarmiello, Loredana F.; Mazzeo, Maria Fiorella; Minasi, Paola; Peluso, Angela; Luca, Antonio De; Piccirillo, Pasquale; Siciliano, Rosa Anna; Carbone, Virginia

doi:10.1021/jf5018324

Cited by 50 publications

(38 citation statements)

References 39 publications

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“…Italy is the second largest hazelnut-producing area (about 105,000 t/year), behind Turkey (about 600,000 t/year) [1]. About 10% of the world crop production is sold as in-shell product consumed fresh or roasted, and the remaining 90% as shelled hazelnuts and used as an ingredient in food (bakery, confectionary industry, and chocolate) processing industries [2,3]. During the kernel harvesting and industrial processing, a large amount of by-products, including green leafy cover, shell and skin, is obtained.…”

Section: Introductionmentioning

confidence: 99%

Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines

Esposito

Sansone

Franceschelli

et al. 2017

IJMS

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Hazelnut shells, a by-product of the kernel industry processing, are reported to contain high amount of polyphenols. However, studies on the chemical composition and potential effects on human health are lacking. A methanol hazelnut shells extract was prepared and dried. Our investigation allowed the isolation and characterization of different classes of phenolic compounds, including neolignans, and a diarylheptanoid, which contribute to a high total polyphenol content (193.8 ± 3.6 mg of gallic acid equivalents (GAE)/g of extract). Neolignans, lawsonicin and cedrusin, a cyclic diarylheptanoid, carpinontriol B, and two phenol derivatives, C-veratroylglycol, and β-hydroxypropiovanillone, were the main components of the extract (0.71%–2.93%, w/w). The biological assays suggested that the extract could be useful as a functional ingredient in food technology and pharmaceutical industry showing an in vitro scavenging activity against the radical 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) (EC50 = 31.7 μg/mL with respect to α-tocopherol EC50 = 10.1 μg/mL), and an inhibitory effect on the growth of human cancer cell lines A375, SK-Mel-28 and HeLa (IC50 = 584, 459, and 526 μg/mL, respectively). The expression of cleaved forms of caspase-3 and poly(ADP-ribose) polymerase-1 (PARP-1) suggested that the extract induced apoptosis through caspase-3 activation in both human malignant melanoma (SK-Mel-28) and human cervical cancer (HeLa) cell lines. The cytotoxic activity relies on the presence of the neolignans (balanophonin), and phenol derivatives (gallic acid), showing a pro-apoptotic effect on the tested cell lines, and the neolignan, cedrusin, with a cytotoxic effect on A375 and HeLa cells.

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Section: Introductionmentioning

confidence: 99%

Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines

Esposito

Sansone

Franceschelli

et al. 2017

IJMS

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“…There have been several reports of the application of MALDI–MS to protein and peptide profiling for the quality evaluation of crude food samples, such as beers 16 , milk, hazelnut 17 , and peanut 18 , but metabolomic applications have proven more challenging. The choice of matrix is one of the most important issues affecting the non-targeted metabolomic analysis of crude extracts.…”

Section: Discussionmentioning

confidence: 99%

A Chemometrics-driven Strategy for the Bioactivity Evaluation of Complex Multicomponent Systems and the Effective Selection of Bioactivity-predictive Chemical Combinations

Fujimura

Kawano

Maeda-Murayama

et al. 2017

Sci Rep

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Although understanding their chemical composition is vital for accurately predicting the bioactivity of multicomponent drugs, nutraceuticals, and foods, no analytical approach exists to easily predict the bioactivity of multicomponent systems from complex behaviors of multiple coexisting factors. We herein represent a metabolic profiling (MP) strategy for evaluating bioactivity in systems containing various small molecules. Composition profiles of diverse bioactive herbal samples from 21 green tea extract (GTE) panels were obtained by a high-throughput, non-targeted analytical procedure. This employed the matrix-assisted laser desorption ionization–mass spectrometry (MALDI–MS) technique, using 1,5-diaminonaphthalene (1,5-DAN) as the optical matrix for detecting GTE-derived components. Multivariate statistical analyses revealed differences among the GTEs in their antioxidant activity, oxygen radical absorbance capacity (ORAC). A reliable bioactivity-prediction model was constructed to predict the ORAC of diverse GTEs from their compositional balance. This chemometric procedure allowed the evaluation of GTE bioactivity by multicomponent rather than single-component information. The bioactivity could be easily evaluated by calculating the summed abundance of a few selected components that contributed most to constructing the prediction model. 1,5-DAN-MALDI–MS-MP, using diverse bioactive sample panels, represents a promising strategy for screening bioactivity-predictive multicomponent factors and selecting effective bioactivity-predictive chemical combinations for crude multicomponent systems.

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“…Among other applications, it has been used to determine the origin of food [69][70][71] and food adulterations [72][73][74][75][76][77]. The discrimination of samples on the basis of their protein fingerprints using MALDI-MS is also an intense area of research [78][79][80].…”

Section: Direct Apci-hrms and Ptr-hrmsmentioning

confidence: 99%

“…A MALDI-TOF MS method was also developed for the authentication and quality control of 29 hazelnut (Corylus avellana L.) cultivars based on the analysis of peptide and protein components [71]. Hazelnut kernel samples were analyzed in the positive-ion mode and acquired in the m/z 3500-15000 range.…”

Section: Direct Apci-hrms and Ptr-hrmsmentioning

confidence: 99%

The role of direct high-resolution mass spectrometry in foodomics

et al. 2015

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Foodomics has been defined as a global discipline in which advanced analytical techniques and bioinformatics are combined to address different questions in food science and nutrition. There is a growing number of works on the development and application of non-targeted omics methods in foodomics, which reflects that this emerging discipline is already considered by the scientific community to be a valuable approach to assess food safety, quality, and traceability as well as for the study of the links between food and health. As a result, there is a clear need for more rapid, high-throughput MS approaches for developing and applying non-targeted studies. Nowadays, direct MS analysis is one of the main choices to achieve high throughput, generating a set of information from the largest possible number of samples in a fast and straightforward way. The use of high- and ultrahigh-resolution MS greatly improves the analytical performance and offers a good combination of selectivity and sensitivity. By using a range of methods for direct sample introduction/desorption/ionization, high-throughput and non-target analysis of a variety of samples can be obtained in a few seconds by HRMS analysis. In this review, a general overview is presented of the main characteristics of direct HRMS-based approaches and their principal applications in foodomics.

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Analysis of Different European Hazelnut (Corylus avellana L.) Cultivars: Authentication, Phenotypic Features, and Phenolic Profiles

Cited by 50 publications

References 39 publications

Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines

Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines

A Chemometrics-driven Strategy for the Bioactivity Evaluation of Complex Multicomponent Systems and the Effective Selection of Bioactivity-predictive Chemical Combinations

The role of direct high-resolution mass spectrometry in foodomics

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