Analysis of dose to the macula, optic disc, and lens in relation to vision toxicities – A retrospective study using COMS eye plaques

Oare, Courtney; Sun, Susan; Dusenbery, Kathryn E.; Reynolds, Margaret; Koozekanani, Dara D.; Gerbi, Bruce J.; Ferreira, Clara

doi:10.1016/j.ejmp.2022.08.001

Cited by 8 publications

(8 citation statements)

References 41 publications

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“…Bearing in mind the limitations mentioned above and comparing the research studies on visual acuity deterioration after Ru-106 brachytherapy, I-125 brachytherapy and proton beam therapy of uveal melanoma published at the turn of the 20th and 21st centuries [ 3 , 30 , 55 , 56 ] and in the last 4 years [ 9 , 11 , 21 , 31 , 33 , 34 , 35 , 37 , 38 , 39 , 41 , 42 , 44 , 49 , 50 , 51 ], we can conclude that the degree of visual impairment is comparable. Considering the extremely dynamic development of medicine and widely understood technology, one would like to achieve greater progress in this field.…”

Section: Discussionmentioning

confidence: 99%

“…The retrospective study included 52 patients treated from 2005 to 2019 with an average follow-up time of 4.0 years (median: 3.6; range: 0.4–13.5 years). Among the many interesting results, the most important seemed to be that, after follow up, 65% of patients presented radiation retinopathy, 65% developed cataracts, 85% had at least a mild change in vision, 40% had moderate vision decline (>5 Snellen lines lost) and 31% eyes became blind (VA = 20/200 or worse) [ 31 ].…”

Section: I-125 Brachytherapymentioning

confidence: 99%

“…According to many previous studies, the frequency of complications after brachytherapy increases with the increase in the dose received by the healthy structures of the eye [ 11 , 31 ]. Fili et al published a study aiming to investigate if a threshold for increased disease-related mortality could be identified within the clinical range of prescribed doses and dose rates among patients treated with ruthenium-106 or iodine-125 brachytherapy for choroidal melanoma.…”

Section: Concepts For Improving Brachytherapy and Proton Therapy In T...mentioning

confidence: 99%

“…After brachytherapy, 49% of eyes experienced vision loss within three years and 68% within ten years. In addition, 45% of patients were qualified as blind (20/200 or worse) within three years post-treatment [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications

2023

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Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. The eyeball is the most common extracutaneous location of melanoma. UM is a huge threat to a patient’s life. It metastasizes distantly via blood vessels, but it can also spread locally and infiltrate extraocular structures. The treatment uses surgical methods, which include, among others, enucleation and conservative methods, such as brachytherapy (BT), proton therapy (PT), stereotactic radiotherapy (SRT), stereotactic radiosurgery (SRS), transpupillary thermotherapy (TTT) and photodynamic therapy. The key advantage of radiotherapy, which is currently used in most patients, is the preservation of the eyeball with the risk of metastasis and mortality comparable to that of enucleation. Unfortunately, radiotherapy very often leads to a significant deterioration in visual acuity (VA) as a result of radiation complications. This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.

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Section: Discussionmentioning

confidence: 99%

Section: I-125 Brachytherapymentioning

confidence: 99%

Section: Concepts For Improving Brachytherapy and Proton Therapy In T...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications

2023

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“…In the field of biological imaging, significant variations in features are often observed among diverse samples, posing a challenge to the generalizability of deep learning-based reconstruction algorithms [ 23 , 24 ]. These disparities can impede the effective application of learned models across different domains.…”

Section: Principlementioning

confidence: 99%

Optical projection tomography reconstruction with few views using highly-generalizable deep learning at sinogram domain

Sun,

Zhao,

Zhu

et al. 2023

Biomed. Opt. Express

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Optical projection tomography (OPT) reconstruction using a minimal number of measured views offers the potential to significantly reduce excitation dosage and greatly enhance temporal resolution in biomedical imaging. However, traditional algorithms for tomographic reconstruction exhibit severe quality degradation, e.g., presence of streak artifacts, when the number of views is reduced. In this study, we introduce a novel domain evaluation method which can evaluate the domain complexity, and thereby validate that the sinogram domain exhibits lower complexity as compared to the conventional spatial domain. Then we achieve robust deep-learning-based reconstruction with a feedback-based data initialization method at sinogram domain, which shows strong generalization ability that notably improves the overall performance for OPT image reconstruction. This learning-based approach, termed SinNet, enables 4-view OPT reconstructions of diverse biological samples showing robust generalization ability. It surpasses the conventional OPT reconstruction approaches in terms of peak-signal-to-noise ratio (PSNR) and structural similarity (SSIM) metrics, showing its potential for the augment of widely-used OPT techniques.

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Radiation Retinopathy

Chen

Browne

2023

Curr Ophthalmol Rep

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Purpose of the Review. In this review, we bring together recent developments in the detection and management of radiation retinopathy. Recent Findings Research into OCT-angiography for radiation retinopathy has led to the identification of biomarkers of early radiation-induced changes in the retinal microvasculature including focal capillary loss and vascular remodeling. These microvasculature changes are detectable after exposure to radiation but prior to the emergence of classical clinical markers historically used to diagnose radiation retinopathy. The ability to detect subclinical changes may present the need to redefine radiation retinopathy diagnostic criteria which may ultimately impact management. Additionally, explorations into prophylactic treatment following radiation exposure and development of newer anti-VEGF agents may present more options for retinal specialists to prevent or treat vision loss and retinal vasculopathy from radiation exposure. Summary Currently, anti-VEGF injections and/or intravitreal steroids remain the primary treatment following a diagnosis of radiation retinopathy. However, a mainstay treatment and management strategy have not yet been identified. In the future, new anatomical endpoints for radiation retinopathy may be identified with OCT-angiography while prophylactic treatment with anti-VEGF agents following radiation therapy may reduce initial vision loss and changes to the retina.

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Analysis of dose to the macula, optic disc, and lens in relation to vision toxicities – A retrospective study using COMS eye plaques

Cited by 8 publications

References 41 publications

Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications

Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications

Optical projection tomography reconstruction with few views using highly-generalizable deep learning at sinogram domain

Radiation Retinopathy

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