2000
DOI: 10.1016/s0925-4773(99)00337-8
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Analysis of Drosophila salivary gland, epidermis and CNS development suggests an additional function of brinker in anterior-posterior cell fate specification

Abstract: Salivary glands are simple structured organs which can serve as a model system in the study of organogenesis. Following a large EMS mutagenesis we have identified a number of genes required for normal salivary gland development. Mutations in the locus small salivary glands-1 (ssg-1) lead to a drastic reduction in the size of the salivary glands. The gene ssg-1 was cloned and subsequent sequence and genetic analysis showed identity to the recently published gene brinker. The salivary gland placode in brinker mu… Show more

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Cited by 15 publications
(13 citation statements)
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“…; Lammel et al 2000), which is less strong than brk M68 shows essentially the same mutant phenotype as brk…”
Section: F124mentioning
confidence: 90%
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“…; Lammel et al 2000), which is less strong than brk M68 shows essentially the same mutant phenotype as brk…”
Section: F124mentioning
confidence: 90%
“…The loss-of-function alleles brk F124 (Lammel et al 2000), brk M68 (Jazwinska et al 1999a), and tsh 8 (Fasano 1991) were used for analysis. The following lacZ reporter constructs were used: RP9, Ubx B , and BM2 (Szüts et al 1998).…”
Section: Fly Stainsmentioning
confidence: 99%
See 1 more Smart Citation
“…Each belt is formed in the anterior region of each segment and is composed of six rows of denticles, with those in rows 1 and 4 pointing anteriorly, whereas the rest point posteriorly (Saller et al, 2002). The VDBs in brk null mutants are severely reduced and exhibit a polarity defect with all remaining denticles pointing posteriorly (Jaźwińska et al, 1999a;Lammel et al, 2000;Saller et al, 2002). Both brk KO and brk 3M have this null phenotype, but it is slightly less severe in brk GM , with the VBDs being wider than in the nulls, although all remaining denticles point posteriorly ( Fig.…”
Section: Yellow Arrowheads) (E-eљ) Brk δ3rcm Clones Sal Is Not Derementioning
confidence: 99%
“…We have analyzed the activity of each of these mutants in different tissues in which Brk is known to function, including (1) the early embryo, where it is expressed in the ventrolateral region and restricts expansion of dorsally expressed genes (Jaźwińska et al, 1999a); (2) later embryos, where it is required to establish the characteristic ventral denticle belts of the larva (Lammel et al, 2000;Saller et al, 2002); (3) in the wing disc, where it is expressed in lateral-to-medial gradients and restricts targets to medial regions (Campbell and Tomlinson, 1999;Jaźwińska et al, 1999b;Minami et al, 1999); and (4) during oogenesis, where it is expressed in the follicle cells surrounding the developing oocyte and is required to help pattern the egg shell (Chen and Schüpbach, 2006). We show that Gro is necessary and sufficient for Brk to function in generating a morphologically wild-type fly, although not efficiently.…”
Section: Introductionmentioning
confidence: 99%