Analysis of drugs, natural and bioactive compounds containing phenolic groups by capillary electrophoresis coupled to mass spectrometry

Huck, Christian W.; Stecher, G.; Scherz, H.; Bonn, Günther K.

doi:10.1002/elps.200410315

Cited by 53 publications

(26 citation statements)

References 103 publications

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“…Rather few papers discuss the use of CE -MS for the determination of flavonoids and phenolic acids [180]. The dearth of applications may evidence that the technique is not considered sufficiently robust and userfriendly by many researchers.…”

Section: Capillary Electrophoretic and Capillary Electrochromatographmentioning

confidence: 99%

Extraction, separation, and detection methods for phenolic acids and flavonoids

Stalikas¹

2007

J of Separation Science

850

539

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ReviewExtraction, separation, and detection methods for phenolic acids and flavonoidsThe impetus for developing analytical methods for phenolic compounds in natural products has proved to be multifaceted. Hundreds of publications on the analysis of this category of compounds have appeared over the past two decades. Traditional and more advanced techniques have come to prominence for sample preparation, separation, detection, and identification. This review provides an updated and extensive overview of methods and their applications in natural product matrices and samples of biological origin. In addition, it critically appraises recent developments and trends, and provides selected representative bibliographic examples.

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Section: Capillary Electrophoretic and Capillary Electrochromatographmentioning

confidence: 99%

Extraction, separation, and detection methods for phenolic acids and flavonoids

Stalikas¹

2007

J of Separation Science

850

539

View full text Add to dashboard Cite

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“…However, problems such as poor separation and low stability after derivatization state are some of the shortcomings of this method. CE is too employed for analysis of phenolic compounds (Huck et al 2005;Butehorn et al 1996). Mostly, the method falls in the field of natural product research, including the analysis of plants, vegetables, herbs, and other plant-or fruit-derived products.…”

Section: Introductionmentioning

confidence: 99%

Method development for simultaneous detection of ferulic acid and vanillin using high-performance thin layer chromatography

Hingse

Digole²,

Annapure

2014

J Anal Sci Technol

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Background: A simple, accurate, and reliable high-performance thin-layer chromatography (HPTLC) method was developed for separation and detection of ferulic acid and vanillin. Methods: Separation of ferulic acid and vanillin was carried out on 20 × 10 cm thin layer chromatography (TLC) plates using mobile phase containing toluene/1, 4-dioxan/acetic acid in the ratio 9:2.5:0.4 (v/v). The FA and vanillin were scanned at 320 and 312 nm, respectively. Method was validated for linearity, accuracy, precision, robustness, limit of detection, limit of quantification, and specificity.

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“…A number of recent reviews have covered the application of CE-MS for drug analysis, with some of them giving the fragmentations, when available, that the ionic species undergo in-source and in IT, triple quadrupole or TOF mass spectrometers [6][7][8][9][10]. This part of the review is dedicated to the analysis of drugs in biological fluids.…”

Section: Ce-ms For Bioanalysis Of Drugsmentioning

confidence: 99%

Capillary electrophoresis‐mass spectrometry, an attractive tool for drug bioanalysis and biomarker discovery

2006

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The coupling of CE with MS detection, a relatively recent hyphenated technique, has gained increasing respect in the field of bioanalytical applications over the past few years. The first part of this review presents CE-MS applications dealing with drug bioanalysis, including forensic analysis and metabolism studies. Practical considerations to achieve a robust and sensitive CE-MS coupling are also presented. It is indeed essential to strictly control some critical electrospray parameters, such as the sheath liquid composition and flow rate, the nebulizing gas pressure as well as the capillary outlet position. The second part of the review critically describes the applications of CE coupled on-line to MS for the identification of biomarkers in body fluids for diagnostic purposes. Since the sample preparation procedures strongly differ according to the intended use (drug bioanalysis or biomarker discovery), they are discussed separately, taking into account the particular properties of plasma and urine matrices.

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Analysis of drugs, natural and bioactive compounds containing phenolic groups by capillary electrophoresis coupled to mass spectrometry

Cited by 53 publications

References 103 publications

Extraction, separation, and detection methods for phenolic acids and flavonoids

Extraction, separation, and detection methods for phenolic acids and flavonoids

Method development for simultaneous detection of ferulic acid and vanillin using high-performance thin layer chromatography

Capillary electrophoresis‐mass spectrometry, an attractive tool for drug bioanalysis and biomarker discovery

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