Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt–Jakob disease

Zerr, Inga; Pocchiari, Maurizio; Collins, Steven J.; Jp, Brandel; Cuesta, Jesús de Pedro; Knight, Richard; Bernheimer, H.; Cardone, Franco; Delasnerie-Lauprêtre, N; Cuadrado-Corrales, Natividad; Ladogana, Anna; Bodemer, Monika; Fletcher, Ashley; Awan, T.; Bremón, A. Ruiz; Budka, Herbert; Laplanche, Jean‐Louis; Will, R. G.; Poser, S.

doi:10.1212/wnl.55.6.811

Cited by 430 publications

(316 citation statements)

References 22 publications

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“…Unfortunately, this finding has a limited sensitivity of approximately 40-67%, only occur relatively late in the disease course and is mainly positive in the MM1 and MV1 molecular subtypes (8,(29)(30)(31)(32). Older age and shorter disease duration are correlated with increased likelihood of a positive test (33).…”

Section: Sporadic Creutzfeldt-jakob Diseasementioning

confidence: 99%

Imaging of prion diseases

Létourneau-Guillon

Wada²,

Kucharczyk

2012

Magnetic Resonance Imaging

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Prion diseases are caused by self‐replicating proteins that induce lethal neurodegenerative disorders. In the last decade, the understanding of the different clinical, pathological, and neuroimaging phenotypes of this group of disorders has evolved paralleling the advances in prion molecular biology. From an imaging standpoint, the implementation of diffusion‐weighted imaging in routine practice has markedly facilitated the detection of prion diseases, especially Creutzfeldt‐Jakob. Less frequent prion‐related disorders, including genetic diseases, may also benefit from progresses in the field of quantitative diffusion‐weighted imaging, MR spectroscopy or molecular imaging. Herein, we present a review of the neuroimaging features of the prion disorders known to affect humans emphasizing the important contribution of MRI in the diagnosis of this group of disorders. J. Magn. Reson. Imaging 2012;35:998‐1012. © 2012 Wiley Periodicals, Inc.

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Section: Sporadic Creutzfeldt-jakob Diseasementioning

confidence: 99%

Imaging of prion diseases

Létourneau-Guillon

Wada²,

Kucharczyk

2012

Magnetic Resonance Imaging

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“…Due to diverse phenotypic heterogeneity of Creutzfeldt-Jakob disease (CJD) and atypical variants [3][4][5] differential diagnosis of CJD from other neurological diseases (sometimes reversible and treatable) is very challenging Initially diagnostic criteria of CJD were based on combination of clinical symptoms and biomarkers such as MRI, EEG and classical CSF protein marker 14-3-3 [6][7][8][9] protein. 14-3-3, which is released into interstitial fluid on death of neurons, indicates rapid neurodegeneration [6].…”

Section: Scjd Subtype Specific Csf Proteins Signaturementioning

confidence: 99%

Subtype Specific CSF Biomarkers in Sporadic Creutzfeldt-Jakob Disease

Zafar¹,

Younas²,

Zerr³

2017

J Alzheimers Dis Parkinsonism

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“…Sie sind ein charakteristischer, jedoch unspezifischer Marker der CJK, so dass das klinische Erscheinungsbild des Patienten immer berücksichtigt werden muss , Zerr et al 2000a. Bereits in einem frühen Krankheitsstadium können die 14-3-3-Proteine mittels Western Blot qualitativ im Liquor cerebrospinalis von sCJK-Patienten nachgewiesen werden , Zerr et al 2000a.…”

Section: Nachweis Der Proteine 14-3-3 Im Liquor Cerebrospinalisunclassified