This article explores the historical transformation of mindfulness, through a process of transculturation and commodification, into a biopolitical tool and analyzes possible future scenarios in which this tool will acquire even greater biopolitical strength through the integration of technological devices and artificial intelligence applications, particularly focusing on the growing divide between mindfulness-based therapies and traditional meditation. While both methodologies share the common objective of providing health and psychophysical benefits, they differ fundamentally in their theoretical frameworks, with mindfulness being egolatric and performance oriented while traditional meditation emphasizes transcending psychophysical identity. The development of mindfulness has been influenced by the sociocultural context of neoliberal and capitalist societies, resulting in a model that fosters self-regulation and emphasizes social control. The article also examines the potential biopolitical risks arising from the integration of AI-powered tools into mindfulness-based therapies. The increasing use of digital devices and applications for monitoring physical and mental health may contribute to a society characterized by constant self-surveillance and self-monitoring, reinforcing biopolitical control of the body. Consequently, this raises critical questions regarding the limits of surveillance and the potential exploitation of vulnerabilities through the incorporation of AI-powered tools.