2010
DOI: 10.1016/j.neuron.2010.12.009
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Analysis of Excitatory Microcircuitry in the Medial Entorhinal Cortex Reveals Cell-Type-Specific Differences

Abstract: Medial entorhinal cortex (MEC) plays an important role in physiological processes underlying navigation, learning, and memory. Excitatory cells in the different MEC layers project in a region-specific manner to the hippocampus. However, the intrinsic microcircuitry of the main excitatory cells in the superficial MEC layers is largely unknown. Using scanning photostimulation, we investigated the functional microcircuitry of two such cell types, stellate and pyramidal cells. We found cell-type-specific intralami… Show more

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Cited by 63 publications
(68 citation statements)
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“…The setup, materials, and methods for photolysis of caged glutamate have been described previously (Bendels et al, 2008;Beed et al, 2010). In brief, 25 ml of ASCF containing 200 M MNI-caged L-glutamate (Tocris) was recirculated at 3-5 ml/min.…”
Section: Methodsmentioning
confidence: 99%
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“…The setup, materials, and methods for photolysis of caged glutamate have been described previously (Bendels et al, 2008;Beed et al, 2010). In brief, 25 ml of ASCF containing 200 M MNI-caged L-glutamate (Tocris) was recirculated at 3-5 ml/min.…”
Section: Methodsmentioning
confidence: 99%
“…The distance d* depends on cell type and laser intensity. It estimates the distance between cell soma and dendritic hot spots, i.e., the location on the dendritic arbor from which an AP is evoked by photolysis of caged glutamate (Shepherd et al, 2003;Bendels et al, 2008;Beed et al, 2010). We generated spatial profiles of AP firing of the main excitatory cells in all layers of the aPC in current clamp.…”
Section: Calibration Of Spatial Resolutionmentioning
confidence: 99%
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“…Further complicating matters, the superficial and deep layers of EC are directly connected with one another intra-cortically, in microcircuits recently reported to differentially impact layer II stellate and layer II/III pyramidal cells [42]. While the functional ramifications of reentrant EChippocampal loops are not yet fully understood, they make defining and decoding the critical elements of such a massively interconnected and reciprocal network challenging.…”
Section: Some Quirks Of Entorhinal-hippocampal Connectivitymentioning
confidence: 99%