Analysis of factors influencing bone ingrowth into three-dimensional printed porous metal scaffolds: A review

Wang, Zhonghan; Wang, Chenyu; Li, Chen; Qin, Yanguo; Zhong, Lei; Chen, Bingpeng; Li, Zhao-Yan; Li, He; Chang, Fei; Wang, Jincheng

doi:10.1016/j.jallcom.2017.05.079

Cited by 234 publications

(127 citation statements)

References 130 publications

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“…[135,136] For years, researchers aimed to improve this process, as poor bone ingrowth may have led to implant loosening, necessitating revision surgery. [137] The vast majority of such experiments were focused mainly on the modification of the surface of dense biomaterials such as roughness and bioactivity.…”

Section: Osseointegration Of Porous Implantsmentioning

confidence: 99%

“…[139] A study by Nadezdhin et al showed an ectopic osteogenesis test which proved better osteogenic and osteoconductive characteristics of porous implants in comparison to the uniform surface configuration of low roughness. [137] In a recent study, Chang et al evaluated titanium scaffolds for bone defect restoration. [137] In a recent study, Chang et al evaluated titanium scaffolds for bone defect restoration.…”

Section: Osseointegration Of Porous Implantsmentioning

confidence: 99%

“…[137] First, pre-shaped implants cannot be used when abnormal anatomical structure is encountered. According to Wang et al, a few deficiencies of these materials exist from a clinical point of view.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

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Porous Titanium Implants: A Review

2018

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Titanium and its alloys are commonly used in almost all disciplines of medicine because of their sufficient biocompatibility and meeting of mechanical requirements. However, dense metallic biomaterials represent only an interfacial connection with host tissue, may develop stress shielding which causes ingrowth of the fibrous tissue, and are prone to microbial adhesion and development of biomaterial associated infections. Therefore, development of a new, porous titanium biomaterial is proposed to improve an implant's interconnection with bone, provide better stabilization, and reduce the risk of the loss of the implant. In this review, recent findings in porous titanium biomaterials engineering are discussed, including the structural and strengthening aspects of titanium alloys. The porosity and design of porous structures, as well as the optimization process are also described. An extensive part of this section is dedicated to manufacturing processes. The next section of the review is devoted to osseointegration of porous implants and surface treatment processes, whose purpose are antibacterial activity or local drug delivery. Summarizing the article, some future predictions have been presented.

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Section: Osseointegration Of Porous Implantsmentioning

confidence: 99%

Section: Osseointegration Of Porous Implantsmentioning

confidence: 99%

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Porous Titanium Implants: A Review

2018

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“…A large number of investigations are therefore concerned with the implementation of implant surfaces with biocompatible or bioactive properties [17][18][19][20]. The aim is to establish conditions that will optimally assist bone in growing in order to achieve maximum secondary stability [21][22][23][24][25].Numerical simulations are also frequently used in the area of implant development as an indispensable link between constructive development ideas and experimental testing [26][27][28][29][30]. The success of an implantation is determined not only by secondary stiffness but also by primary anchoring strength [29,31,32].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Experimental Characterization of the Primary Stability of Acetabular Press-Fit Cups with Open-Porous Load-Bearing Structures on the Surface Layer

Weißmann

Boss²,

Schulze

et al. 2018

Metals

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Background: Nowadays, hip cups are being used in a wide range of design versions and in an increasing number of units. Their development is progressing steadily. In contrast to conventional methods of manufacturing acetabular cups, additive methods play an increasingly central role in the development progress. Method: A series of eight modified cups were developed on the basis of a standard press-fit cup with a pole flattening and in a reduced version. The surface structures consist of repetitive open-pore load-bearing textural elements aligned right-angled to the cup surface. We used three different types of unit cells (twisted, combined and combined open structures) for constructing of the surface structure. All cups were manufactured using selective laser melting (SLM) of titanium powder (Ti6Al4V). To evaluate the primary stability of the press fit cups in the artificial bone cavity, pull-out and lever-out tests were conducted. All tests were carried out under exact fit conditions. The closed-cell polyurethane (PU) foam, which was used as an artificial bone cavity, was characterized mechanically in order to preempt any potential impact on the test results. Results and conclusions: The pull-out forces as well as the lever moments of the examined cups differ significantly depending on the elementary cells used. The best results in pull-out forces and lever-out moments are shown by the press-fit cups with a combined structure. The results for the assessment of primary stability are related to the geometry used (unit cell), the dimensions of the unit cell, and the volume and porosity responsible for the press fit. Corresponding functional relationships could be identified. The findings show that the implementation of reduced cups in a press-fit design makes sense as part of the development work.beyond the current state of the art, for example in the field of orthopedics, is an interesting task for development engineers. Due to their outstanding mechanical and biocompatible properties, titanium and titanium alloys, in addition to other materials, are at the center of development work [5][6][7].Of major interest is the implementation of open-porous structures in orthopedic implants. These structural elements provide excellent conditions to fulfil structural and functional requirements. Open-porous structures meet the mechanical requirements regarding surface quality as well as those regarding design conditions [8][9][10]. In addition, such structures offer a potential for solving the problems of different stiffnesses between human bone and full implants [11,12]. As a result of their geometry, open-pore structures offer the cells good conditions for nutrient supply, and consequently, the possibility to grow well into the pores. Characteristic features of open-pore structures like pore size and distribution as well as connectivity affect biological processes like cell migration and proliferation and as a result the regeneration process [3,13].The applications of open-porous and load-bearing structures in orthopedic ap...

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Orthopedic Implant Design and Analysis: Potential of3D/4DBioprinting

Wang

Hazlehurst²

2018

3D and 4D Printing in Biomedical Applications

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Analysis of factors influencing bone ingrowth into three-dimensional printed porous metal scaffolds: A review

Cited by 234 publications

References 130 publications

Porous Titanium Implants: A Review

Porous Titanium Implants: A Review

Experimental Characterization of the Primary Stability of Acetabular Press-Fit Cups with Open-Porous Load-Bearing Structures on the Surface Layer

Orthopedic Implant Design and Analysis: Potential of3D/4DBioprinting

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