A proper dressing for chronic wounds should be able to
preserve
moisture while absorbing the exudates and exhibit good antibacterial
properties and reliable mechanical properties. Furthermore, drug delivery
through a wound dressing is an added value that brings more therapeutic
and regenerative functionalities. In this study, a carboxylated multiwalled
carbon nanotube–curcumin hybrid composite was embedded in a
polyamide 6/poly(vinyl alcohol) nanofibrous composite (PA6/PVA/CMWCNT-Cur)
for controlled drug release and potential wound healing application.
PA6/PVA/CMWCNT-Cur nanofibrous composites were synthesized in two
steps. First, Cur was loaded throughout the CMWCNT, and then a cross-linked
PA6/PVA/CMWCNT-Cur blend solution was electrospun at CMWCNT-Cur concentrations
of 0.5, 0.75, and 1 wt %. The results showed that incorporating PVA
and CMWCNT-Cur into the PA6 nanofiber improved its wettability, physical
properties, and biodegradability. In addition, the optical density
technique demonstrated that the produced nanofibers had high antibacterial
activity, which effectively inhibited the development of Staphylococcus
aureus and Escherichia coli bacteria. Due
to its uniform nanofibrous structure, superior mechanical capabilities,
and excellent antibacterial features, the PA6/PVA/CMWCNT-Cur hybrid
nanofibrous composite containing 0.75 wt % CMWCNT-Cur was chosen as
the most suitable sample. Studies on the release of Cur from the nanofibers
at different pH values demonstrated a faster rate in mild acidic media.
The cell viability against the L929 cell line showed that the PA6/PVA/CMWCNT-Cur
hybrid nanofibrous composite significantly increased the cell viability
and proliferation. This work provides a simple and quick strategy
for producing a multifunctional nanofibrous mat for wound healing
applications.