Analysis of gene expression by nCounter Nanostring technology in medical research: experience with children with nephrotic syndrome

Морозов, С. Л.; Voronkova, A. S.; Dlin, V. V.; Turkina, T. I.; Sukhorukov, V. S.

doi:10.21508/1027-4065-2019-64-1-110-115

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…По данным различных авторов, генетические факторы, влияющие на индивидуальный фармакодинамический и фармакокинетический профиль, могут составлять от 20 до 95% вариабельности эффективности и развития нежелательных явлений от препаратов, используемых для лечения нефротического синдрома [5,[8][9][10].…”

Section:  персонализированная медицина в педиатрической нефрологииunclassified

Nephrotic Syndrome: Could Personalized Therapy Be Possible? A Review

Длин¹,

Морозов²

2023

Педиатрия. Восточная Европа

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Термину «персонализированная медицина» чуть более 20 лет, но индивидуальные подходы к терапии пациентов существуют уже более ста лет. Расшифровка генома и развитие фармакогенетики в последние десятилетия открыли новые пути развития медицины и новое понимание понятия «персонализированная медицина». Активное развитие принципов персонализированного подхода к диагностике и лечению в педиатрической нефрологии, особенно с использованием современных молекулярно-генетических методов, не только в разы увеличит диагностические возможности в верификации заболеваний почек, но и позволит определиться с индивидуальной терапией для каждого конкретного ребенка. Это приведет к повышению эффективности лечения, снижению серьезных нежелательных явлений проводимой терапии и существенному улучшению качества жизни, социального и витального прогноза. В статье на примере глюкокортикоидной терапии при нефротическом синдроме у детей продемонстрирована важность изучения генетических факторов, влияющих на индивидуальный фармакодинамический и фармакокинетический профиль глюкокортикостероидов. The term "personalized medicine" is just over 20 years old, but individual approaches to patient therapy have been around for over a hundred years. Decoding the human genome and pharmacogenetics development in recent decades have opened up new paths for medicine development and a new understanding of the concept of "personalized medicine". An active development of principles for personalized approach to diagnosis and treatment in pediatric nephrology, especially with use of modern molecular genetic methods, would not only multiply diagnostic opportunities in kidney disease verification, but also would allow determining an individual therapy for each particular child. This will lead to improvement of treatment efficacy, to reduction of serious adverse events of therapy applied and to significant improvement of the quality of life and both social and vital prognosis. The article demonstrates the importance of studying genetic factors influencing the individual pharmacodynamic and pharmacokinetic profile of glucocorticosteroids using glucocorticosteroids therapy for nephrotic syndrome in children as an example.

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Section:  персонализированная медицина в педиатрической нефрологииunclassified

Nephrotic Syndrome: Could Personalized Therapy Be Possible? A Review

Длин¹,

Морозов²

2023

Педиатрия. Восточная Европа

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Mycophenolate mofetil in therapy of primary nephrotic syndrome in children

KURSOVA

Petrosyan

Piruzieva

et al. 2023

Ross. vestn. perinatol. pediatr.

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Idiopathic nephrotic syndrome is the most common glomerular disease in children, with a prevalence of 1.15–16.9 cases per 100,000 children per year worldwide. In some cases, nephrotic syndrome has a frequently relapsing course or dependence on steroid therapy is formed, which leads to the appointment of immunosuppressive therapy. So far, in clinical practice, there is no unambiguous approach among physicians to the management of patients with nephrotic syndrome, especially when it comes to the further choice of immunosuppressive therapy. Because of the serious side effects of long-term corticosteroid use, doctors prescribe steroid adjuvants to maintain remission and limit the cumulative effect of glucocorticosteroids. Among adjuvants, mycophenolate mofetil, with mycophenolic acid as the active ingredient, is believed to be the most preferred option due to fewer adverse events, acceptable tolerability and, at the same time, high efficacy. This article describes the advantages and features of the use of mycophenolic acid in clinical practice, provides data on pharmacodynamics and drug monitoring, and discusses issues of personalized medicine.

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RNA analysis as a promising area of diagnostics in nephrology

Morozov,

Pakhomova,

Voinova

et al. 2023

Ross. vestn. perinatol. pediatr.

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Today, medicine is at a stage when traditional diagnostic tools no longer meet current needs, which has led to the rapid development of molecular diagnostic methods that not only complement traditional research methods but also provide insight from the point of view of molecular pathophysiology. mRNA analysis is a new field that could revolutionize the diagnosis and treatment of kidney disease. The study of mRNA can be used for diagnosing and classifying kidney diseases, predicting the progression of nephropathies, monitoring the effectiveness of treatment, and developing modern approaches to therapy. As a new field, mRNA analysis faces a number of challenges and limitations, but as technology advances, the technique becomes more accessible for clinical use.

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Analysis of gene expression by nCounter Nanostring technology in medical research: experience with children with nephrotic syndrome

Cited by 4 publications

References 14 publications

Nephrotic Syndrome: Could Personalized Therapy Be Possible? A Review

Nephrotic Syndrome: Could Personalized Therapy Be Possible? A Review

Mycophenolate mofetil in therapy of primary nephrotic syndrome in children

RNA analysis as a promising area of diagnostics in nephrology

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