Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster

Koksal, Pakize Muge; Gürbüzel, Mehmet

doi:10.1016/j.etap.2014.12.010

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…Rocuronium bromide is a frequently used commercial muscle relaxants and produced under the trade name Esmeron®. 17 According to UV-vis spectroscopy, pillar[5]arene 3 has one absorption maximum with λ max at 292 nm in water. The rocuronium bromide solution does not absorb in the wavelength range studied (200 -600 nm).…”

Section: Resultsmentioning

confidence: 99%

Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

et al. 2019

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“…Thus, our study only evaluated patients who underwent minor surgeries (septoplasty or tympanoplasty) to minimize the possible influence of trauma on the comet assay results. All other drugs used in the study have been reported as nongenotoxic, such as fentanyl [Brambilla and Martelli, ] and rocuronium [Koksal and Gürbüzel, ]. Additionally, previous work has not found evidence of genotoxicity following anesthesia with propofol, fentanyl, and rocuronium (the same protocol used in this study) and sevoflurane [Orosz et al, ].…”

Section: Discussionmentioning

confidence: 69%

Evaluation of genotoxicity of general anesthesia maintained with desflurane in patients under minor surgery

Nogueira

Braz

Andrade

et al. 2016

Environ and Mol Mutagen

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There is controversy over the genotoxic effects of volatile anesthetics. The available literature on the genotoxicity of desflurane, one of the newest volatile halogenated agents used for general anesthesia maintenance, is scarce. This study aimed to evaluate the genotoxic potential of desflurane in 15 patients without comorbidities, of both sexes, who underwent minor surgeries lasting at least 90 min. Patients enrolled in the study received desflurane anesthesia (6%); blood samples were collected before anesthesia induction (T0), 90 min after the beginning of anesthesia (T1), and on the day following surgery (T2). DNA damage was evaluated in lymphocytes using the alkaline comet assay. We found statistically significant increases in DNA damage in T2 samples compared to T0. The findings suggest that desflurane anesthesia induces DNA strand breaks/alkali-labile sites on the day after minimally invasive surgery in healthy patients.

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“…The SMART assay is a practical test for potential chronic use and overdosing genotoxic property assessment of pharmaceutical agents [ 44 , 45 ]. Several studies confirmed SMART as a suitable in vivo test to evaluate the genotoxicity of anesthetic agents.…”

Section: Applications Of Smart In Drug Safety Assessmentmentioning

confidence: 99%

Human Hazard Assessment Using Drosophila Wing Spot Test as an Alternative In Vivo Model for Genotoxicity Testing—A Review

Pitchakarn

Inthachat

Karinchai

et al. 2021

IJMS

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Genomic instability, one of cancer’s hallmarks, is induced by genotoxins from endogenous and exogenous sources, including reactive oxygen species (ROS), diet, and environmental pollutants. A sensitive in vivo genotoxicity test is required for the identification of human hazards to reduce the potential health risk. The somatic mutation and recombination test (SMART) or wing spot test is a genotoxicity assay involving Drosophila melanogaster (fruit fly) as a classical, alternative human model. This review describes the principle of the SMART assay in conjunction with its advantages and disadvantages and discusses applications of the assay covering all segments of health-related industries, including food, dietary supplements, drug industries, pesticides, and herbicides, as well as nanoparticles. Chemopreventive strategies are outlined as a global health trend for the anti-genotoxicity of interesting herbal extract compounds determined by SMART assay. The successful application of Drosophila for high-throughput screening of mutagens is also discussed as a future perspective.

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Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster

Cited by 8 publications

References 41 publications

Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

Evaluation of genotoxicity of general anesthesia maintained with desflurane in patients under minor surgery

Human Hazard Assessment Using Drosophila Wing Spot Test as an Alternative In Vivo Model for Genotoxicity Testing—A Review

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