Analysis of gold nanoparticles using ICP-MS-based hyphenated and complementary ESI-MS techniques

Helfrich, Andreas; Bettmer, Jörg

doi:10.1016/j.ijms.2011.01.010

Cited by 61 publications

(37 citation statements)

References 42 publications

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“…Selected references for detailed information on the application of ICP-MS in characterizing metal nanoparticles include the following: Telgmann et al (2014), Tadjiki et al (2013), Crayton (2012), Daniela et al (2012), Mitrano et al (2012, Gschwind et al (2011), Helfrich and Bettmer (2011), Jimenez et al (2010, and Allabashi et al (2009). …”

Section: Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Experimental Methodologies for the Characterization of Nanoparticles

Singh

2016

Engineered Nanoparticles

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Section: Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Experimental Methodologies for the Characterization of Nanoparticles

Singh

2016

Engineered Nanoparticles

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“…All chemicals were used as received without further purification. Gold nanoparticle suspensions (5, 10,15,20,30,40, and 50 nm, stabilized by citrate with a net negative surface charge) were acquired from Ted Pella (Redding, CA, USA) and stored at 4°C. A total of four commercially available dietary supplements (labeled as DS 1−4) which claim the inclusion of nanomaterials or the utilization of nanotechnology were purchased from Internet resources.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Capillary Electrophoresis/Inductively-Coupled Plasma-Mass Spectrometry: Development and Optimization of a High Resolution Analytical Tool for the Size-Based Characterization of Nanomaterials in Dietary Supplements

Mudalige

Linder

2014

Anal. Chem.

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We report the development and optimization of a system consisting of capillary electrophoresis (CE) interfaced with inductively coupled plasma mass spectrometry (ICPMS) for rapid and high resolution speciation and characterization of metallic (e.g., gold, platinum, and palladium) nanoparticles in a dietary supplement. Multiple factors, including surfactant type and concentration, pH of running buffer, and applied voltage, were investigated to optimize the separation conditions. It was found that by using the anionic surfactant sodium dodecyl benzenesulfonate (SDBS) in the running buffer the separation resolution was significantly improved, allowing for easy distinction of adjacent size fractions in a gold nanoparticle mixture with very small size differences (e.g., 5, 15, 20, and 30 nm). The type and concentration of the surfactant was found to be critical in obtaining sufficient separation while applied voltage and pH values of the running buffers largely affected the elution times by varying the electroosmotic flow. Quantum dots were used as mobility markers to eliminate the run-to-run variation. The diameters of the nanoparticles followed a linear relationship with their relative electrophoretic mobility, and size information on unknown samples could be extrapolated from a standard curve. The accuracy and precision of this method was confirmed using 10 and 30 nm gold nanoparticle standard reference materials. Furthermore, the method was successfully applied to the analysis of commercially available metallic nanoparticle-based dietary supplements, as evidenced by good agreement between the particle sizes calculated by CE/ICPMS and transmission electron microscopy (TEM).

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“…Therefore, the design, synthesis, characterization, and applications of nanostructures are critical aspects for the emerging eld of nanomaterials (NMs). This is the case of inductively coupled plasmamass spectrometry (ICP-MS), 7 but this application eld is still in its beginning regarding the common whole actual applications of ICP-MS. 8 Field ow fractionation (FFF) have also been used for NPs separation coupled to ICP-MS as a detector. 2 In general, scientists rely almost exclusively on electron microscopy (EM) 3 and dynamic light scattering (DLS), 4 to characterize the size distributions of solution-grown NPs, such as gold NPs (AuNPs).…”

Section: Introductionmentioning

confidence: 99%

“…2 In general, scientists rely almost exclusively on electron microscopy (EM) 3 and dynamic light scattering (DLS), 4 to characterize the size distributions of solution-grown NPs, such as gold NPs (AuNPs). 8 Chromatographic methods, such as size exclusion chromatography (SEC) 10 have been proved its usefulness for characterizing the size of AuNPs. Additionally, DLS cannot separate the contributions of the various NP sizes in the population from the total correlation function.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to size separation of gold nanoparticles by capillary electrophoresis–evaporative light scattering detection

et al. 2015

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A simple and rapid methodology to separate and characterize gold nanoparticles (AuNPs) in aqueous medium by capillary electrophoresis-evaporative light scattering detection (CE-ELSD) is presented.First, a controlled synthesis procedure to obtain water-soluble AuNPs, by varying the trisodium citrate concentration was described. These free AuNPs were separated by capillary zone electrophoresis (CZE) based on the differences in the charge-to-mass ratio of the AuNPscitrate in a mixed buffer of ammonium acetate (20 mM), containing tris(hydroxymethyl)-aminomethane (Tris, 20 mM) and 3-(cyclohexylamino)-1-propanesulfonic acid (CAPS; 10 mM) at pH 8.5.Under optimal working conditions, three small different-sized AuNPs were successfully separated whose average sizes were 3.5, 6.5 and 10.5 nm. The average diameter was lower than 1.2 nm for all of them (calculated by high-resolution transmission electron microscopy, TEM). Thus, this CE-based method was able to separate AuNPs that differ by only 3 nm in diameter. It can be a valuable methodology for the rapid and cost-effective characterization of other nanomaterials in the future in aqueous solutions.

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Analysis of gold nanoparticles using ICP-MS-based hyphenated and complementary ESI-MS techniques

Cited by 61 publications

References 42 publications

Experimental Methodologies for the Characterization of Nanoparticles

Experimental Methodologies for the Characterization of Nanoparticles

Capillary Electrophoresis/Inductively-Coupled Plasma-Mass Spectrometry: Development and Optimization of a High Resolution Analytical Tool for the Size-Based Characterization of Nanomaterials in Dietary Supplements

A novel approach to size separation of gold nanoparticles by capillary electrophoresis–evaporative light scattering detection

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