Analysis of gut microbiota and intestinal integrity markers of inpatients with major depressive disorder

Liśkiewicz, Paweł; Kaczmarczyk, Mariusz; Misiak, Błażej; Wroński, Michał; Bąba-Kubiś, Agata; Skonieczna-Żydecka, Karolina; Marlicz, Wojciech; Bieńkowski, Przemysław; Misera, Agata; Pełka-Wysiecka, Justyna; Kucharska-Mazur, Jolanta; Konopka, Anna; Łoniewski, Igor; Samochowiec, Jerzy

doi:10.1016/j.pnpbp.2020.110076

Cited by 56 publications

(53 citation statements)

References 98 publications

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“…The diversity of the gut microbiota appears to play a significant role in the occurrence of mood and anxiety disorders [50][51][52][53]: for example, Clostridia were consistently found to be reduced in number, or absent, in those with depression, independent of the presence of anxiety, while the numbers of Bacteroides may be more associated with the presence of anxiety, irrespective of the presence of depression. Changes in the gut microbiota population have been associated with the severity of depressive symptoms in clinical population [54,55]: These differences suggest that the distribution of gut microbiota could help clarify the underlying pathology of comorbid clinical presentation [56]. Additionally, the degree of intestinal integrity and levels of inflammation markers have been found to be associated with the severity of depressive symptoms and response to treatment [54].…”

Section: Microbiota As a Connecting Factormentioning

confidence: 99%

“…Changes in the gut microbiota population have been associated with the severity of depressive symptoms in clinical population [54,55]: These differences suggest that the distribution of gut microbiota could help clarify the underlying pathology of comorbid clinical presentation [56]. Additionally, the degree of intestinal integrity and levels of inflammation markers have been found to be associated with the severity of depressive symptoms and response to treatment [54]. However, little is known on how microbiota health is associated with specific features of DDs.…”

Section: Microbiota As a Connecting Factormentioning

confidence: 99%

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Adiposity in Depression or Depression in Adiposity? The Role of Immune-Inflammatory-Microbial Overlap

Gawlik-Kotelnicka

Strzelecki

2021

Life

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Some of the most common and debilitating conditions are metabolic disorders (metabolic syndrome and non-alcoholic fatty liver disease) and depression. These conditions are also exacerbated by the fact that they often co-occur. Although the exact mechanisms underlying such relationships are poorly known, antipsychotic medication and antidepressant use, diet and physical activity, and lifestyle factors are believed to play a role; however, their high co-occurrence rate suggests a possible pathophysiological overlap. This paper reviews several possible bases for this overlap, including hypothalamic-pituitary-adrenal axis dysregulation, immune alterations with chronic inflammation, and oxidative stress. While it is entirely possible that changes in the microbiota may play a role in each of them, interventions based on the implementation of dietary and other lifestyle changes, supplementation with prebiotics or probiotics and faecal microbiota transplantation have failed to achieve conclusive results. A better characterization of the above associations may allow a more targeted approach to the treatment of both depressive and metabolic disorders. The paper also presents several practical applications for future studies.

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Section: Microbiota As a Connecting Factormentioning

confidence: 99%

Section: Microbiota As a Connecting Factormentioning

confidence: 99%

Adiposity in Depression or Depression in Adiposity? The Role of Immune-Inflammatory-Microbial Overlap

Gawlik-Kotelnicka

Strzelecki

2021

Life

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“…intestinal integrity and inflammation markers were associated with the response to treatment and severity of depressive symptoms 46 . However, little is known on how microbiota health is associated with specific features of DDs.…”

mentioning

confidence: 99%

“…The diversity of the gut microbiota has emerged to play a significant role in the occurrence of mood and anxiety disorders [42][43][44][45] . In recent studies gut microbiota taxonomical changes were associated with the severity of depressive symptoms in clinical population 46,47 . Reduced or absent Clostridia was consistently seen in those with depression, independent of the presence of anxiety.…”

mentioning

confidence: 99%

Adiposity in Depression or Depression in Adiposity? the Role of Immune-Inflammatory-Microbial Overlap

Gawlik-Kotelnicka¹

2021

Preprint

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Metabolic disorders, metabolic syndrome and non-alcoholic fatty liver disease, and depression are those of the most common and debilitating disorders worldwide that often coexist further increasing mortality risks. Although the exact mechanisms underlying this association are poorly known, several hypotheses have been proposed: antipsychotic medication and antidepressants use, diet and physical activity or any other lifestyle factors. However, the high co-occurrence rate of depression and metabolic disorders suggests a possible pathophysiological overlap. In this paper I review several raised mechanisms for this overlap which are the hypothalamic-pituitary-adrenal axis dysregulation, immune alterations with chronic inflammation, as well as oxidative stress. In my view, there is one common thread running through all the aforementioned areas of pathophysiology which is microbiota alteration. So far, several possible interventions in our microbiota have been introduced into clinical practice - dietary and other lifestyle changes, supplementation with prebiotics or probiotics, fecal microbiota transplantation – but with vague indications. A better characterization of the above associations may represent a critical step at phenotyping, and a more targeted approach to the treatment of both depressive and metabolic disorders. At the end of the paper, I give several practical applications for future studies.

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“…The enriched microbiota in the DL macaques mainly belonged to the family Paraprevotella, and the depleted species mainly belonging to the genera Gemella and Streptococcus. Paraprevotella has been suggested as a biomarker in depression[37,38] and attention deficit hyperactivity disorder[39], as well as a potential factor to inhibit plasma acetate levels and intrarenal RAS…”

mentioning

confidence: 99%

Changes in Gut Viral and Bacterial Species Correlate with Altered 1,2-Diacylglyceride Levels and Structure in the Prefrontal Cortex in a Non-Human Primate Model of Depression.

Wu¹,

Chai²,

Zhang³

et al. 2020

Preprint

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Background: Major depressive disorder (MDD) is a debilitating mental disease, but its underlying molecular mechanisms remain obscure. Gut microbiome can modulate brain function and behaviors through the microbiota-gut–brain (MGB) axis in depression. Our previously established non-human primate model of naturally occurring depression-like behaviors, which is characterized by MGB axis disturbances, can be used to interrogate how a disturbed gut ecosystem may modulate the MDD onset. To better clarify the molecular interrelationships and downstream functional consequences in the MGB axis on MDD pathology, here, gut metagenomics were used to characterize how gut virus and bacterial species, and associated metabolites, change in depressive monkey model.Results: We identified a panel of 33 gut virus and 14 bacterial species that could discriminate the depression-like (DL) from control M. fascicularis. In addition, using lipidomic analyses of central and peripheral samples obtained from these animals, we found that the DL macaque were characterized by alterations in the relative abundance, carbon-chain length, and unsaturation degree of 1,2-diacylglyceride (DG) in the prefrontal cortex (PFC), in a brain region-specific manner. In addition, lipid-reaction analysis identified more active and inactive lipid pathways in PFC than in amygdala or hippocampus, with DG being a key nodal player in these lipid pathways. Significantly, co-occurrence network analysis showed that altered gut viral and bacterial species, and their interaction may be relevant to the onset of negative emotions behaviors by modulating the DG levels in PFC in the depressive macaque. Conclusions: Our findings suggest that altered gut virus and bacteria as well as DG levels and structure in the PFC are hallmarks of the DL macaque, thus providing a new framework for understanding the gut microbiome's role in depression.

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Analysis of gut microbiota and intestinal integrity markers of inpatients with major depressive disorder

Cited by 56 publications

References 98 publications

Adiposity in Depression or Depression in Adiposity? The Role of Immune-Inflammatory-Microbial Overlap

Adiposity in Depression or Depression in Adiposity? The Role of Immune-Inflammatory-Microbial Overlap

Adiposity in Depression or Depression in Adiposity? the Role of Immune-Inflammatory-Microbial Overlap

Changes in Gut Viral and Bacterial Species Correlate with Altered 1,2-Diacylglyceride Levels and Structure in the Prefrontal Cortex in a Non-Human Primate Model of Depression.

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