Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats

Li, X.; Jiang, Yuehua; Jiang, Ping; Lin, Haiqing; Yang, Jinlong; Ma, Daifu; Wang, X.; Yang, Chuanhua

doi:10.1055/s-0035-1547258

Cited by 14 publications

(19 citation statements)

References 21 publications

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“…Streptozotocin has been widely used for inducing diabetes mellitus in a variety of animals. STZ causes degeneration and necrosis of pancreatic β-cells [2][3][4][5]. Although the mechanism of the β-cell cytotoxic action of STZ is not fully understood, experimental evidence has demonstrated that some of its deleterious effects are attributable to induction of metabolic processes, which lead onto an increase in the generation of reactive oxygen species (ROS) [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Low Intensity Exercise Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Heart

Kanter

Aksu

Takır

et al. 2016

Exp Clin Endocrinol Diabetes

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The aim of this study was to investigate the effects of low intensity exercise on heart of streptozotocin (STZ)-induced diabetic rats. The rats were randomly divided into 3 experimental groups: A (control), B (diabetic untreated), and C (diabetic treated with low intensity exercise); each group contains 8 animals. B and C groups received STZ. Diabetes was induced in 2 groups by a single intraperitoneal (i.p) injection of STZ (40 mg/kg, freshly dissolved in 0,1 M citrate buffer, pH 4.2). 2 days after STZ treatment, diabetes in 2 experimental groups was confirmed by measuring blood glucose levels. Rats with blood glucose levels of 250 mg/dl or higher were considered to be diabetic. Animals in the exercise group were made to run the treadmill once a day for 4 consecutive weeks. Exercise started 3 days prior to STZ administration. After induction of diabetes, histological abnormalities were observed, including myofibrillar loss, vacuolization of cytoplasm and irregularity of myofibrils. These alterations were attenuated by low intensity exercise. Our data indicates a significant reduction of oxidative stress and apoptosis in cardiomyocytes after exercise. Treatment of diabetic animals with low intensity exercise, decreased the elevated tissue malondialdehyde (MDA) levels and increased the reduced activities of the enzymatic antioxidants superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in cardiac tissue. These findings suggest that low intensity exercise has a therapeutic protective effect in diabetes by decreasing oxidative stress and apoptosis, and by preservation of myocardial integrity.

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Section: Introductionmentioning

confidence: 99%

Effects of Low Intensity Exercise Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Heart

Kanter

Aksu

Takır

et al. 2016

Exp Clin Endocrinol Diabetes

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“…In agreement with these results, it has been shown that kefir reduced pro-inflammatory cytokines, including TNFα, in DM [168,195]. The secondary outcomes included an improved lipid profile, blood pressure and hs-CRP, but kefir administration did not significantly change these parameters [191]. In contrast with experimental studies, it is still not clear whether kefir has beneficial effects on the lipid profile.…”

Section: Beneficial Effects Of Probiotics: Highlights Of Treatmentmentioning

confidence: 79%

“…For example, in the model of type 1 DM, an important imbalance of the cardiac autonomic nerves, located at both tissues and molecular pathways, has been observed. Recently, in the first 10 weeks of experimental DM, a marked cardiac dysfunction and an incomplete recovery of the cardioinhibitory vagal nerves, accompanied by a remodeling process in the stimulatory noradrenergic nerves [191], have been shown.…”

Section: Beneficial Effects Of Probiotics: Highlights Of Treatmentmentioning

confidence: 99%

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Pereira

Pimenta

Porto

et al. 2016

IJMS

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Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and treatment has been a constant challenge for basic and clinical investigators focused on translating their discoveries into clinical treatment of this complex disorder. In this review, we highlight recent experimental and clinical evidences of potential coadjuvants in the management of DM, such as polyphenols (quercetin, resveratrol and silymarin), cultured probiotic microorganisms and drugs acting through direct/indirect or pleiotropic effects on glycemic control in DM. Among several options, we highlight new promising therapeutic coadjuvants, including chemical scavengers, the probiotic kefir and the phosphodiesterase 5 inhibitors, which besides the reduction of hyperglycemia and ameliorate insulin resistance, they reduce oxidative stress and improve endothelial dysfunction in the systemic vascular circulation. In the near future, experimental studies are expected to clear the intracellular pathways involving coadjuvants. The design of clinical trials may also contribute to new strategies with coadjuvants against the harmful effects of diabetic complications.

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“…Our results are consistent with those of studies showing the relatively early onset (at 3 weeks) of parasympathetic failure in STZ-induced diabetic rats. 25,26 In those studies, the mechanisms proposed to underlie autonomic neuropathy were depletion of cholinergic neurotransmitter vesicles in cardiac parasympathetic nerve endings 26 and autonomic nerve remodeling via the modulation of enzymes involved in neurotransmitter synthesis. 25 In our study, although there was no evaluation of the neuronal ultrastructural or biochemical changes, similar mechanisms are possibly taking place in the same type of diabetes model.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Magnesium Treatment on Heart Rate Variability and Cardiac Ventricular Function in Diabetic Rats

Amoni

Kelly-Laubscher

Blackhurst

et al. 2016

J Cardiovasc Pharmacol Ther

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Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats

Abstract: STZ-induced diabetes was associated with cardiac autonomic nerve dysfunction at both the organ and molecular levels. Parasympathetic nerves exhibited severe damage and/or weak recovery; remodeling of sympathetic nerves predominated during 10-weeks of STZ-induced diabetes.

Cited by 14 publications

References 21 publications

Effects of Low Intensity Exercise Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Heart

Effects of Low Intensity Exercise Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Heart

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Beneficial Effects of Magnesium Treatment on Heart Rate Variability and Cardiac Ventricular Function in Diabetic Rats

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