Analysis of histomorphological spectrum of gestational trophoblastic diseases: Clinico-Radio-Pathological correlation at a tertiary care teaching hospital

K, Anandraj Vaithy; Samal, Rupal; Raghavan, Atm Venkat; Subramanian, Sowmya

doi:10.18231/j.jdpo.2021.014

Cited by 2 publications

(5 citation statements)

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“…Similarly, the cases of GTD were more common in a primigravida with 28(43.08%) cases with decreasing frequencies in subsequent gravida, second gravida, third gravida, fourth gravida, and fifth gravida as 22(33.85%) and nine(13.85%), four(6.15%), two(3.07%) cases respectively. These findings were similar to various studies conducted by Vaithy K et al, Jagtap SV et al, Tanwar RK et al 4,5,7 However, this was in contrast to the study conducted by Anyanwu M et al and Pritam A et al, where GTD was more common in multigravida with 16 (80%) cases and 23 (62.16%) cases respectively. 9,12 In this study, suction and evacuation were performed in almost all cases of hydatidiform moles and hydropic abortus, whereas a hysterectomy was done in one case of choriocarcinoma.…”

Section: Discussionsupporting

confidence: 90%

“…This was similar to the study conducted by Vaithy KA et al, where out of 160 cases of GTD, 92(57.5%) cases were of partial mole and 32(20%) cases of complete mole, 13(8.1%) cases of choriocarcinoma and 17(10.6%)cases of Placental site trophoblastic tumor. 4 Likewise, in a study conducted by Jaiswal P et al, out of 141 cases, 110 (71.0%) were partial mole, 15(9.7%) complete mole, 12(7.7%) invasive mole, three (1.9%) persistent mole and one (0.6%) choriocarcinoma. 10 The mean age of presentation in this study was 25.4 years which was in concordance with other studies by Jagtap SV et al and Veeraraghavan G et alwith 24.5, and 23.5 years respectively.…”

Section: Discussionmentioning

confidence: 93%

“…However, the disease is more prevalent among Asians with 0.5-3/1000 pregnancies. 4 The total number of deliveries during the period of five years from January 2016 to December 2020 was 14,742, out of which 65 cases of GTD were diagnosed. So, the prevalence of GTD in this tertiary care hospital was 4 per 1000 deliveries (0.4% or 1:227 deliveries).…”

Section: Discussionmentioning

confidence: 99%

“…A similar study conducted by Vaithy KA et al, Jagtap SV et al, and Koirala A et al showed an incidence of 4 per 1000 deliveries. 4,5,8 However, the incidence of GTD varies significantly across the world with 0.4 per 1000 birth in the United States of America, 12.5 per 1000 births in Taiwan to 9.46 per 1000 patients in Gambia, West Africa. 8,9 Likewise, in our country, Nepal, considering the data of various hospitals within the Kathmandu valley, the incidence of GTD is ranging from 2.8 to 5.1 per 1000 deliveries.…”

Section: Discussionmentioning

confidence: 99%

“…Early pregnancy vaginal bleeding is the most common clinical presentation along with elevation of B-hCG (usually >10,000 mIU/ml). 4 Though the disease is more prevalent in Asian countries, there is limited information on GTD from Nepal. Till now there is no published data on the magnitude of the GTD problem among women admitted at Dhulikhel hospital.…”

Section: Introductionmentioning

confidence: 99%

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Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

et al. 2022

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Introduction: Gestational trophoblastic diseases, because of their diverse presentation and the malignant lesions being associated with recurrence, metastasis, and mortality, early diagnosis is important with the help of ultrasonogram preoperatively, serial Beta human chorionic gonadotropin, and histopathological examination for prompt treatment and timely management of the patients. The study aimed to identify the overall prevalence and relative frequencies of Gestational trophoblastic diseases and to assess the association of different gestational trophoblastic diseases with maternal age, parity, and gestational age.Materials and Methods: This is a retrospective cross-sectional study conducted for five years from January 2016 to December 2020 in the Department of Pathology, and Department of gynecology and obstetrics of Dhulikhel Hospital, Kavre Nepal. This study included a spectrum of gestational trophoblastic diseases. All the details were obtained from the patient’s record file and register book. Results: Out of 65 cases, the most common was Hydatidiform mole with 59 (90.78%) cases. Bleeding per vagina was the most common clinical presentation. The most commonly affected age group was 21-25 years. Most of the gestational trophoblastic diseases were detected in the first trimester and primigravida.Conclusions: Any pregnant woman presenting with abnormal uterine bleeding should be evaluated for the presence of underlying Gestational trophoblastic disease. Beta-hCG is a sensitive marker, however, histopathology remains a gold standard modality for the detection of gestational trophoblastic diseases. The judicious use of ultrasonograms and appropriate clinicopathological approach helps the clinician to decide the treatment modalities, especially between evacuation and hysterectomy.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

et al. 2022

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A study on histomorphological analysis of gestational trophoblastic disease

Neral,

Varma,

Grihi

et al. 2024

MGM J Med Sci

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Background: Gestational trophoblastic disease (GTD) represents a diverse group of conditions characterized by abnormal trophoblastic proliferation within the placenta. GTD includes benign and malignant lesions, ranging from complete and partial hydatidiform moles to more severe forms like invasive moles, choriocarcinoma, placental site trophoblastic tumors (PSTTs), and epithelioid trophoblastic tumors. Given that neoplastic GTD lesions respond remarkably well to chemotherapy, early and accurate histopathological diagnosis is crucial as it directly influences treatment and prognosis. Aim and Objectives: This study examined the histomorphological features of various types of GTD alongside key clinical factors such as age, parity, and gestational period. Materials and Methods: The study was conducted in the Department of Pathology over the course of10 years, from January 2014 to January 2024. All cases of GTD confirmed through histopathological examination of hematoxylin and eosin-stained slides were included in the analysis. Results: Out of 60 diagnosed cases of GTD, 34 (56.66%) were complete hydatidiform moles, 22 (36.67%) were partial hydatidiform moles, 1 (1.67%) was an invasive mole, 1 (1.67%) was choriocarcinoma, and 2 (3.33%) were PSTTs. The age of the affected patients ranged from 18 to 45 years, with the highest incidence observed in the 20–25 year age group (30 cases, 50%). Most cases (33, 55%) occurred during the first trimester, with a predominance among primigravida patients (28 cases, 46.66%). The most common clinical presentation was per vaginal bleeding, reported in 56 cases (93.33%). Conclusion: Although GTD can lead to serious complications, including metastasis, it is treatable. In this study, the complete hydatidiform mole was the most frequently encountered lesion and is associated with a higher risk of severe complications such as persistent GTD, invasive moles, and choriocarcinoma. Thus, early and accurate histopathological diagnosis is vital for the timely initiation of therapy, ultimately reducing the mortality rate. This study highlights the various categories and histomorphological features of GTD, emphasizing the importance of understanding its clinical presentation to mitigate disease burden and complications.

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Analysis of histomorphological spectrum of gestational trophoblastic diseases: Clinico-Radio-Pathological correlation at a tertiary care teaching hospital

Cited by 2 publications

References 3 publications

Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

A study on histomorphological analysis of gestational trophoblastic disease

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