Analysis of histopathological aspects in acquired middle ear cholesteatoma

Alves, Adriana Leal; Pereira, Celina Siqueira Barbosa; Ribeiro, Fernando de Andrade Quintanilha; Fregnani, José Humberto Tavares Guerreiro

doi:10.1016/s1808-8694(15)30143-9

Cited by 16 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, cystic content is formed of keratin lamellae [42]. The matrix exhibited different features which were positively correlated to each other including atrophy, acanthosis, basal cell hyperplasia, and epithelial cones formation into the perimatrix [43]. The degree of inflammation of the perimatrix is positively related to its thickness [44].…”

Section: Histology Of Cholesteatomamentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

show abstract

Section: Histology Of Cholesteatomamentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…1 This description is supported by histologic studies of cholesteatoma that demonstrate an intrusion into the middle ear of keratinizing stratified squamous epithelium surrounded by a peri-matrix of fibroblasts and inflammatory cells. 2 However, this simple description tends to minimize the aggressiveness of the disease process.…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐8 production in response to tumor necrosis factor‐alpha by cholesteatoma keratinocytes in cell culture

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Tal dado corrobora com o aumento do nível inflamatório adjacente à camada epitelial dos animais, relacionado ao contato com o agente clareador. Em estudo de Alves et al 17 (2008), ao estudarem o desenvolvimento de colesteatomas, uma associação positiva no aumento hiperplásico, formação de cones epiteliais e processo inflamatório foi encontrada, o que também foi encontrado no presente estudo.…”

Section: Discussionunclassified

Influência do peróxido de carbamida sobre a gengiva marginal – estudo em camundongos

Acasigua

Marques

Fossati

2016

Rev. da Fac. de Odontologia, UPF

View full text Add to dashboard Cite

IntroduçãoExiste um aumento expressivo da demanda por serviços relacionados à harmonização corporal, o que se reflete na exponencial procura por tratamentos odontológicos estéticos, como o clareamento dental. Desde que foi descrito em 1989, tal procedimento encontra-se cada vez mais difundido na prática odontológica 1 . Enquanto grandes empresas cosméticas vendem o procedimento de clareamento dental como minimamente invasivo e seguro, pesquisadores questionam os potenciais efeitos nocivos de tal procedimento, tais como o efeito carcinogê-nico e a capacidade de injúrias aos tecidos moles e mineralizados 2,3 . A terapia clareadora consiste em utilização tópi-ca, sobre o dente, de um agente oxidante (peróxido de carbamida ou de hidrogênio) capaz de quebrar macromoléculas que o pigmentam. De maneira geral, a concentração utilizada desses agentes depende da técnica empregada. É importante ressaltar que existem duas técnicas distintas para o procedimento de clareamento dental. Na técnica de clareamento dental em consultório, o paciente submete--se ao procedimento sob supervisão do cirurgião-

show abstract

Analysis of histopathological aspects in acquired middle ear cholesteatoma

Abstract: Cholesteatomas have hyperproliferating characteristics with epithelial acanthosis, hyperplasia of the basal layer and the presence of epithelial cones in the matrix.

Cited by 16 publications

References 12 publications

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Interleukin‐8 production in response to tumor necrosis factor‐alpha by cholesteatoma keratinocytes in cell culture

Influência do peróxido de carbamida sobre a gengiva marginal – estudo em camundongos

Contact Info

Product

Resources

About