Analysis of influencing factors of no/low response to preoperative concurrent chemoradiotherapy in locally advanced rectal cancer

Abstract

The aim of this study is to investigate the influencing factors associated with no/low response to preoperative concurrent chemoradiotherapy (CCRT) for locally advanced rectal cancer (LARC) patients. A total of 79 patients were included in this prospective study. Fifteen factors that might affect the resistance to CCRT were included in this logistic regression analysis, these factors include the general clinical data of patients, the expression status of tumor stem cell marker CD44v6 and the volumetric imaging parameters of primary tumor lesions. We found that the no/low response status to preoperative CCRT was positively correlated with the real tumor volume (RTV), the total surface area of tumor (TSA), and CD44v6 expression, whereas negatively correlated with the tumor compactness (TC). According to the results of logistic regression analysis, two formulas that could predict whether or not no/low response to preoperative CCRT were established. The Area Under Curve (AUC) of the two formulas and those significant measurement data (RTV, TC, TSA) were 0.

Screening of MicroRNA Related to Irradiation Response and the Regulation Mechanism of miRNA-96-5p in Rectal Cancer Cells

“…Previous studies have shown that both c-Myc (65, 66) and CD44 (67-71) have the characteristics of tumor stem cell marker factors, so we believe that the two genes are eligible for irradiation resistance markers. In fact, the positive correlation between the expression level of these two genes and tumor irradiation resistance has also been confirmed in several studies (72)(73)(74)(75)(76)(77). Therefore, we speculated that the regulation of miRNA-96-5p on irradiation resistance of rectal cancer cells was not only related to the abnormal activation of Wnt signal transduction pathway, but also may be related to the "stem" characteristics of tumor cells.…”